Publication

[Advanced Science] A scalable system was proposed to generate pre-vascularized and functional human beige adipose tissue organoids using the human stromal vascular fraction of white adipose tissue as a source of adipose and endothelial progenitors.

[Frontiers in Cell and Developmental Biology] Investigators performed a detailed functional characterization of human intestinal organoid cultures under different conditions with the aim to suggest an optimized ex-vivo model to further analyze inflammation-induced intestinal epithelial barrier dysfunction.

[Frontiers in Cell and Developmental Biology] The authors assessed the effect of cigarette smoke-exposure and the endoplasmic reticulum stress inducer Thapsigargin on Wnt/β-catenin signaling activation in MRC-5 fibroblasts, and on their ability to support lung epithelial organoid formation.

[BMC Cancer] The TRIPLEX study was a single-center observational study conducted to investigate the feasibility of generating patient-derived tumor organoids from triple negative breast cancer and to evaluate their ability to predict clinical response.

[Reproductive Sciences] To facilitate in vitro mechanistic studies in pelvic inflammatory disease and subsequent tubal factor infertility, researchers established patient tissue derived fallopian tube organoids.

[Cancer Cell International] Immunohistochemistry and western blotting were used to detect the expression level of ADP ribosylation factor 6 (ARF6) in HCC tissues. Investigators analyzed the clinical significance of ARF6 in primary HCC patients.