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Somatic Rearrangements Causing Oncogenic Ectodomain Deletions of FGFR1 in Squamous Cell Lung Cancer

[Journal Of Clinical Investigation] To understand the mechanism of FGFR1 dependency, investigators performed deep genomic characterization of 52 squamous cell lung carcinomas with 8p11-p12-amplification, including 10 tumors obtained from patients who had been treated with FGFR inhibitors.

FSP1 Confers Ferroptosis Resistance in KEAP1 Mutant Non-small Cell Lung Carcinoma in NRF2-Dependent and -Independent Manner

[Cell Death & Disease] Scientists conducted a thorough investigation of the genomic and transcriptomic data derived from hundreds of human cancer cell lines and primary tissue samples, with a particular focus on NSCLC.

6-Shogaol Prevents Benzo (a) Pyrene-Exposed Lung Carcinogenesis via Modulating PRDX1-Associated Oxidative Stress, Inflammation, and Proliferation in Mouse Models

[Environmental Toxicology] Researchers investigated the chemopreventive role of 6-shogaol on benzopyrene-exposed lung carcinogenesis by modulating PRDX1-associated oxidative stress, inflammation, and proliferation in Swiss albino mouse models.

A First-in-Class Pan-Lysyl Oxidase Inhibitor Impairs Stromal Remodeling and Enhances Gemcitabine Response and Survival in Pancreatic Cancer

[Nature Cancer] Using small-molecule drug-design approaches, the authors generated and validated PXS-5505, a first-in-class highly selective and potent pan-lysyl oxidase inhibitor.

FcγRIIB Expressed on CD8+ T Cells Limits Responsiveness to PD-1 Checkpoint Inhibition in Cancer

[Science Translational Medicine] Researchers showed that despite exhibiting strong proliferative and cytokine responses at baseline, human FcγRIIBpos CD8+ T cells exhibited reduced responsiveness to both PD-1 and CTLA-4 checkpoint inhibition as compared with FcγRIIBneg CD8+ T cells in vitro.

Multi-Modal Single Cell Sequencing of B Cells in Primary Sjögren’s Syndrome

[Arthritis & Rheumatology] Over 230 000 B cells were isolated from peripheral blood of primary Sjögren's syndrome patients and four healthy controls, and processed for single cell RNA and VDJ sequencing.

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