Publication

[Functional & Integrative Genomics] Scientists explored the influence of myelin protein zero-like protein 1 (MPZL1) on the stem-like properties of cancer cells and the underlying mechanism in lung adenocarcinoma.

[Nature Medicine] In this Phase IIa, placebo-controlled, double-blinded trial, 43 people with HIV-1 on antiretroviral therapy were randomized to placebo/placebo, lefitolimod/placebo, placebo/broadly neutralizing anti-HIV-1 antibodies (bNAbs) or lefitolimod/bNAb.

[European Journal Of Immunology] Investigators explored the role of vaccine antigen-specific regulatory T (Treg) cells in antibody response to repeated annual influenza vaccination. They analyzed pre- and post-vaccination hemagglutination inhibition titers, seroconversion rates, seroprotection rates, vaccine antigen hemagglutinin-specific Treg cells, and conventional T cells.

[Journal Of Immunology] Scientists demonstrated that mycobacterial cell-wall glycolipids such as ManLAM could traffic from infected macrophages to disrupt productive immunological synapse formation and inhibit CD4+ T cell activation, contributing to immune evasion by M. tuberculosis.

[Developmental And Comparative Immunology] Researchers used a detoxified Salmonella Gallinarum (SG) strain to deliver a dual prokaryotic and eukaryotic expression vector, pJHL270 that expressed recombinant H9N2 antigens in both Salmonella and host cells. They evaluated the H9N2 antigen and SG-specific humoral and cellular immune responses in vitro following immunization.

[Signal Transduction And Targeted Therapy] Investigators developed six human monoclonal antibodies (mAbs) from two elite convalescents in Wuhan and showed that these mAbs recognize diverse epitopes on the receptor binding domain and can inhibit the infection of SARS-CoV-2 original strain and variants.