Publication

[Nature Communications] Researchers found that the small molecule idronoxil inhibits TANK-binding kinase 1/IκB kinase-ε (TBK1/IKKε) signaling through destabilization of TBK1/IKKε protein complexes.

[Nature Communications] Scientists showed that heparan sulfate binds spikes and promotes spike-induced ACE2 clustering, forming synapse-like cell-cell contacts that facilitate fusion pore formation between ACE2-expressing and spike-transfected human cells.

[Communications Biology] To gain insight into the immunogenic characteristics of epitopic sites, researchers systematically investigated the structures of 340 Abs and 83 nanobodies complexed with the Receptor Binding Domain of the SARS-CoV-2 spike protein.

[Scientific Reports] Investigators employed computational protein design and molecular dynamics to investigate and enhance the binding affinity of Beta-27 Fab to SARS-CoV-2-RBD Omicron variant.

[Science] Using mucosal samples obtained at colonoscopy from more than 150 individuals, scientists characterized the healthy human gut γδ T cell population.

[Journal Of Hepatology] Investigators analyzed the transcriptomic profiling at a single-cell resolution within tumor tissues from hepatocellular carcinoma patients scheduled to receive anti-PD-1-based immunotherapy.