Publication

[Experimental & Molecular Medicine] Using single-cell RNA sequencing and immunofluorescence, scientists demonstrated a liver-like cellular repertoire, a higher order cellular complexity, presenting with vascular luminal structures, and a population of resident macrophages: Kupffer cells.

[BMC Medicine] Investigators established a large-scale patient-derived high-risk colorectal adenoma organoid biobank containing 37 patient-derived organoid lines derived from 33 patients.

[Advanced Healthcare Materials] Researchers developed a tuneable hydrogel with spatiotemporal control of stiffness and mesh-network. The volume of MCF7 spheroids encapsulated in a linear stiffness gradient demonstrated an inverse relationship with stiffness.

[Cell Reports Methods] The authors developed a cost-effective strategy for manufacturing molecularly double-barcoded DNA arrays that allowed large-scale spatially resolved transcriptomics studies.

[eLife] Scientists reported self-formation of human telencephalon-eye organoids comprising concentric zones of telencephalic, optic-stalk, optic-disc, and neuroretinal tissues along the center-periphery axis.

[Respiratory Research] Using the innovative approach of using nasal conditionally reprogrammed cell-based models that mimic patient disease in vitro, investigators theratyped orphan cystic fibrosis transmembrane conductance regulator mutation L1077P.