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Hematopoiesis News
Feasibility of Peripheral Blood Stem Cell Collection from Sickle Cell Trait Donors with an Intensified G-CSF Regimen
[European Journal Of Haematology] In this retrospective analysis, researchers compared the safety and efficacy of peripheral stem cell mobilization with a G-CSF intensified mobilization regimen in sickle cell trait donors with a conventional G-CSF mobilization regimen in healthy donors.
Hematopoiesis News
Phase I Study Evaluating the FC-Optimized FLT3 Antibody FLYSYN in AML Patients with Measurable Residual Disease
[Journal Of Hematology & Oncology] This first-in-human, open-label, single-arm, multicenter trial included AML patients in complete remission with persisting or increasing measurable residual disease and evaluated safety/tolerability, pharmacokinetics and preliminary efficacy of FLYSYN at different dose levels administered intravenously.
Endothelial Cell News
Effect of Caffeine and Other Xanthines on Liver Sinusoidal Endothelial Cell Ultrastructure
[Scientific Reports] Cultured primary rat liver sinusoidal endothelial cells were challenged with xanthines at concentrations typically obtained from normal consumption of xanthine-containing beverages, food or medicines; and at higher concentrations below the in vitro toxic limit.
Dermal Cell News
Lineage Commitment of Dermal Fibroblast Progenitors Is Controlled by Kdm6b-Mediated Chromatin Demethylation
[EMBO Journal] Scientists used multimodal single-cell approaches, epigenetic assays, and allografting techniques to define a dermal fibroblast progenitor state and the mechanism that governed its differentiation potential.
Dermal Cell News
Endogenous Rab38 Regulates LRRK2’s Membrane Recruitment and Substrate Rab Phosphorylation in Melanocytes
[Journal of Biological Chemistry] Investigators identified Rab38 as a novel physiologic regulator of leucine-rich repeat kinase 2 (LRRK2) in melanocytes.
Dermal Cell News
Bazi Bushen Alleviates Skin Senescence by Orchestrating Skin Homeostasis in SAMP6 Mice
[Journal Of Cellular And Molecular Medicine] To investigate the potential mechanism, senescence-accelerated mouse prone 6 (SAMP6) was intragastrically administered with Bazi Bushen for nine weeks to induce skin homeostasis.