Publication

[Signal Transduction And Targeted Therapy] Investigators resolved the near-atomic cryo-EM structure of respiratory syncytial virus (RSV) nucleoprotein-RNA that represents roughly one turn of the helical assembly that unveils critical interaction interfaces of RSV nucleocapsid and may facilitate the development of RSV antiviral therapy.

[Nature Immunology] Researchers measured the peripheral immune profiles of 206 vaccinated or unvaccinated adults to determine how baseline variations in the cellular and humoral immune compartments contribute independently or synergistically to the risk of developing symptomatic influenza.

[Journal Of Clinical Investigation] Scientists showed influenza A virus infection blocked defensive alveolar wall liquid secretion and induced airspace liquid absorption, thereby reversing normal alveolar liquid dynamics and inhibiting alveolar clearance of inhaled Staphylococcus aureus.

[Journal Of Infectious Diseases] The effects of calcitonin gene-related peptide (CGRP) on bacterial meningitis (BM) and the underlying mechanisms were investigated in BM mice in vivo and macrophages in vitro. When the underlying mechanisms were investigated, researchers found that CGRP induced proteasome-dependent degradation of MHC-II in macrophages and then inhibits CD4+ T cell activation.

[ACS Applied Bio Materials] Investigators developed a mixed nano micelle drug delivery system for simultaneous targeting of HIV-infected CD4+ T cells with two drugs, suberoylanilide hydroxamic acid and phorbol 12-myristate 13-acetate.

[JNCI-Journal Of The National Cancer Institute] Researchers quantified reinfection risks for patients undergoing distinct antineoplastic therapies, given alternative frequencies of boosting with Pfizer-BioNTech BNT162b2.