Publication

[Cell Reports] Investigators showed that individuals 70 years or older who received a primary two-dose schedule with AZD1222 and booster third dose with mRNA vaccine achieve significantly lower neutralizing antibody responses against SARS-CoV-2 spike pseudotyped virus compared with those younger than 70 at 1 month post booster.

[Scientific Reports] Through llama immunization campaigns, scientists identified single-domainn antibodies that are cross-reactive against multiple emergent coronaviruses. Importantly, a number of these antibodies showed sub-nanomolar potency towards all SARS-like viruses including emergent CoV-2 variants.

[Nature Immunology] Bulk RNA-seq of sorted human exTreg cells identified them as inflammatory and cytotoxic CD4+T cells that were significantly distinct from both natural killer and Treg cells.

[Cell] To depict NK cells' phenotypic and functional diversities in the tumor microenvironment, researchers performed integrative single-cell RNA sequencing analyses on NK cells from 716 patients with cancer, covering 24 cancer types.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Using the model, scientists measured T cell bispecific antibodie-mediated CD8+ T cell activation and killing of RMF- human leukocyte antigen-A2-presenting cells in the presence of peripheral blood mononuclear cells and multiple tool compounds.

[Nature Communications] By analysing lymphocytes from matched human tumor and peripheral blood samples, investigators showed that TIGIT and CD226 co-expression was rare on tumor-infiltrating lymphocytes.