Publication

[Cancer Research Communications] Researchers performed a bioinformatic analysis of adenosine-to-inosine (A-to-I) RNA editing in human melanoma samples and determined that pre-therapy levels of A-to-I RNA editing negatively correlate with survival times.

[Science Advances] To treat unilateral limbal stem cell (LSC) deficiency, scientists developed CALEC using an innovative xenobiotic-free, serum-free, antibiotic-free, two-step manufacturing process for LSC isolation and expansion onto human amniotic membrane.

[Cancer Research] The authors reported that solid tumors released small extracellular vesicles that carried both targeted tumor antigens and the immune checkpoint protein PD-L1.

[Advanced Healthcare Materials] Investigators reported the development of an ionizable lipid nanoparticle platform for simultaneous therapeutic mRNA expression and RNAi-mediated transient gene knockdown in T cells.

[Cancer Letters] Researchers proposed a combination of elements for the construction of superior pluripotent CAR-T cells to provide an effective strategy for the treatment of intractable solid tumors.

[Molecular Therapy Oncolytics] Scientists suggested that armed CD19 CARs with hypoxia-controlled interleukin (IL)-12 might be a promising and safer approach for treating Diffuse Large B cell Lymphoma.