Publication

[Advanced Science] Mesenchymal stromal cells and peripheral blood mononuclear cells coculture are used to construct hepatocellular carcinoma organoid-on-a-chip mimicking original tumor microenvironment.

[Journal of the American Society of Nephrology] Using kindey organoid models, the authors revealed the regulatory mechanisms of HNF4A and HNF4G during human proximal tubule differentiation.

[Cell Reports] Investigators showed that protocadherin 12 (PCDH12) loss severely impaired cerebral organoid development, with reduced proliferative areas and disrupted laminar organization.

[eLife] Scientists showed that in human brain slices, rubella virus predominantly infects microglia. By using an organoid-microglia model, they further demonstrated that the infection led to an interferon response in non-microglial cells.

[Lab On A Chip] Researchers elaborated on the advantages of the designed controllable perfusion microfluidic chip to promote retinal organoid growth.

[Scientific Reports] Scientists developed a monolayer model with an effective barrier function for absorption, distribution, metabolism, and excretion (ADME) assays using rat duodenal organoids as a cell source.