Publication

[Cell Death & Disease] Investigators orchestrated the cellular and spatial architecture of multiple primary lung cancers (MPLCs) by combining single-cell RNA-sequencing and spatial transcriptomics. Notably, they identified a previously undescribed sub-population of epithelial cells termed as CLDN2+ alveolar type II which was specifically enriched in MPLCs.

[Molecular & Cellular Proteomics] To illuminate the molecular basis linking acquired mutation to tyrosine kinase inhibitor (TKI) resistancee, affinity purification coupled mass spectrometry was adopted to dissect epidermal growth factor receptor interactome in TKI-sensitive and -resistant NSCLC cells.

[Scientific Reports] Scientists employed a range of techniques, including qPCR, immunoblotting, co-immunoprecipitation, chromatin-immunoprecipitation, and cell migration assays, in conjunction with online database analysis, to investigate the role of histone deacetylase inhibitors and histone deacetylase 2 (HDAC2)/YY1 in the process of lung adenocarcinoma migration.

[Cell Communication And Signaling] The effects of growth differentiation factor-11 (GDF-11) on CGB expression and human chorionic gonadotropin production, as well as the underlying mechanisms, were explored by a series of in vitro experiments.

[Veterinary Research Communications] Canine amnion membrane-MSCs were more effective than oclacitinib in the recovery of wound dysfunction, regulation of mast cell activity, and expression level of immune modulation protein.

[Bjog-An International Journal Of Obstetrics And Gynaecology] Scientists compared lambs that received an umbilical cord-MSC patch with a control group of lambs that received an acellular patch.