Publication

[Stem Cell Reviews And Reports] Investigators analysed the anti-inflammatory properties of umbilical cord MSC-derived extraceullar vesiscles ‘primed’ with pro-inflammatory cytokines, and at baseline with no inflammatory cytokines.

[Nature Genetics] Researchers developed a targeted proteomic proximity labeling approach to capture transposable element (TE)-associated proteins in hESCs. They found that the RNA N6-methyladenosine (m6A) reader, YTHDC2, occupied genomic loci of the primate-specific TE, LTR7/HERV-H.

[Nature Biomedical Engineering] By using Cas9 to edit the functional BRCA2 allele in the locally haploid hPSCs and in fibroblasts differentiated from them, scientists characterized essential regions in the gene to identify permissive and loss-of-function mutations.

[Nature Structural & Molecular Biology] Because totipotency is not completely understood, investigators carried out a genome-wide CRISPR knockout screen in mouse ESCs, searching for mutants that reactivate the expression of Dazl, a gene expressed in 2-cell-like cells.

[Ebiomedicine] Mouse ovarian granulosa cell derived-iPSCS were labelled with green fluorescent protein reporter and differentiated in vitro into oocytes.

[Cellular And Molecular Life Sciences] On the basis of Yamanaka factors OSKM induction method, MEF cells were induced and reprogrammed into iPSCs under conditions of the oocyte-derived factor Wdr82 overexpression and/or knockdown, so as to assess the reprogramming efficiency.