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The Role of SARS-CoV-2-Mediated NF-κB Activation in COVID-19 Patients

[Hypertension Research] Scientists summarize the role of NF-κB activation during SARS-CoV-2 invasion and replication, particularly the angiotensin-converting enzyme 2-mediated NF-κB activation.

A Guide to Epigenetics in Leukemia Stem Cells

[Molecular Oncology] Scientists discuss the key principles of deregulation of epigenetic processes that shape leukemia stem cells' evolution. They also discuss efforts to identify mechanisms of resistance, by longitudinal analysis of patient samples.

Regulatory Role of RNA Modifications in the Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

[Heliyon] The authors provide a comprehensive overview of RNA modifications in PDAC treatment, encompassing their behaviors, mechanisms, and potential treatment targets.

Nanotechnology-Based Techniques for Hair Follicle Regeneration

[Biomaterials] Scientists review hair follicle-specific targeting strategies, with particular emphasis on currently used nanotechnology-based strategies for both hair loss-related diseases and hair follicle regeneration.

Synthetic Transcription Factor Engineering for Cell and Gene Therapy

[Trends In Biotechnology] Recent advances in human-derived DNA-binding domains (DBDs) and transcriptional activation domains (TADs) paired with novel control modules responsive to clinically approved small molecules have poised the synTF field to overcome these hurdles.

Mind the GAP: RASA2 and RASA3 GTPase-Activating Proteins As Gatekeepers of T Cell Activation and Adhesion

[Trends in Immunology] Although many studies have helped to elucidate the signaling intermediates that mediate T cell activation, the molecules and pathways that keep naive T cells in check are less understood.

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