Cross Talk between Mesenchymal and Glioblastoma Stem Cells: Communication beyond Controversies

The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cellā€cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
[Stem Cells Translational Medicine]
Bajetto, A., Thellung, S., Dellacasagrande, I., Pagano, A., Barbieri, F., & Florio, T. (n.d.). Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0161 Cite
Full Article
Bookmark

No account yet? Register

0
Share

BRAF Mutated Colorectal Cancer: New Treatment Approaches

The authors study the biology of a subgroup of colon cancer harboring a BRAF mutation, to understand the current approach in clinical research.
[Cancers]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Organoid Models for Mammary Gland Dynamics and Breast Cancer

The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast.
[Current Opinion in Cell Biology]
Abstract
Bookmark

No account yet? Register

0
Share

Regulation of Heterogeneous Cancer-Associated Fibroblasts: The Molecular Pathology of Activated Signaling Pathways

Pro-inflammatory cytokines, such as leukemia inhibitory factor and interleukin-6, were secreted by both cancer cells and cancer associated fibroblasts (CAFs), and mediated the epigenetic modification of CAFs. This enhanced the pro-tumorigenic function of CAFs mediated by promoting actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration.
[Journal of Experimental & Clinical Cancer Research]
Full Article
Bookmark

No account yet? Register

0
Share

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

Several of the cytokines involved in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs). JAK inhibition, therefore, presents an attractive therapeutic strategy for cytokine release syndrome, which is a common cause of adverse clinical outcomes in COVID-19.
[Trends in Pharmacological Sciences]
Luo, W., Li, Y.-X., Jiang, L.-J., Chen, Q., Wang, T., & Ye, D.-W. (2020). Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19. Trends in Pharmacological Sciences, 0(0). https://doi.org/10.1016/j.tips.2020.06.007 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Variations in Killer-Cell Immunoglobulin-Like Receptor and Human Leukocyte Antigen Genes and Immunity to Malaria

Understanding the role of killer-cell immunoglobulin-like receptors and human leukocyte antigens in immunity to malaria can help to better characterize antimalarial immune responses. The authors summarize the different KIRs and HLAs associated with immunity to malaria thus far.
[Cellular & Molecular Immunology]
Full Article
Bookmark

No account yet? Register

0
Share

From Threat to Cure: Understanding of Virus-Induced Cell Death Leads to Highly Immunogenic Oncolytic Influenza Viruses

The authors discuss strategies for targeting viral replication to cancerous lesions and arming them with immunogenic transgenes. They describe which modes of cell death are induced by influenza A virus infection and how these insights may be utilized to optimize influenza A virus-based oncolytic virus design.
[Cell Death Discovery]
Full Article
Bookmark

No account yet? Register

0
Share

Considering How Biological Sex Impacts Immune Responses and COVID-19 Outcomes

The authors discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity and highlight potential sex differences underlying COVID-19 severity.
[Nature Reviews Immunology]
Full Article
Bookmark

No account yet? Register

0
Share

Transplanting Neural Progenitor Cells to Restore Connectivity after Spinal Cord Injury

The authors focus on the use of neural progenitor cells obtained or derived from different sources to promote connectivity in sensory, motor and autonomic systems.
[Nature Reviews Neuroscience]
Fischer, I., Dulin, J. N., & Lane, M. A. (2020). Transplanting neural progenitor cells to restore connectivity after spinal cord injury. Nature Reviews Neuroscience, 1–18. https://doi.org/10.1038/s41583-020-0314-2 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Tooth Formation: Are the Hardest Tissues of the Human Body Hard to Regenerate?

Approaches for whole-tooth regeneration utilizing adult stem cells, iPSCs, or tooth germ cells transplantation are emerging as promising alternatives to overcome existing in vitro tissue generation hurdles. The authors discuss the most recent advances in cellular signaling guiding dental tissue genesis.
[International Journal of Molecular Sciences]
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Cancer Stem Cells in Soft-Tissue Sarcomas

The authors review the published evidence of cancer stem cells (CSCs) in soft tissue sarcoma (STS), discussing the molecular characteristic of CSCs, the commonly used isolation techniques and the new possibilities of targeting CSCs as a way to improve STS treatment and consequently patient outcome.
[Cells]
Full Article
Bookmark

No account yet? Register

0
Share
Share