Review

[Life Science Alliance] Recent technological advances have unveiled molecular features that characterize totipotent cells. Single-cell or low-input sequencing technologies allow the dissection of pre- and post-fertilization developmental processes at the molecular level with high resolution.

[Periodontology 2000] New evidence provides a strong impetus to explore heparan sulfate as a potential novel therapeutic agent to treat periodontitis, support alveolar bone maintenance, and promote bone formation.

[Trends In Molecular Medicine] SVEP1 is contained within the extracellular matrix and circulates in plasma, making it a priority candidate for disease diagnostics, prognostics, and therapeutics.

[Trends In Endocrinology And Metabolism] The authors showcase recent studies on the splicing and alternative splicing of key genes in metabolic pathways in the liver, the effect of metabolic signals on the spliceosome, and therapeutic intervention points based on RNA splicing.

[Molecular Psychiatry] Scientists review the mechanisms of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) expression and activation and discussed the role of active NLRP3 inflammasome in the pathogenesis of neurodegenerative diseases, particularly focusing on Alzheimer’s disease.

[Genes & Development] Investigators provide an overview of the intercellular division of metabolic labor that occurs in both the normal brain and the glioblastoma (GBM) tumor microenvironment and then discuss the implications of these interactions for GBM therapy..