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Ambient Temperature, Heat Stress and Fetal Growth: A Review of Placenta-Mediated Mechanisms

[Molecular And Cellular Endocrinology] The authors first summarize evidence linking ambient temperature or experimentally-induced heat stress with fetal and placental growth outcomes in humans, ruminants, and murine species. They then synthesize the literature on putative underlying biological pathways with a focus on the placenta.

Primary Sclerosing Cholangitis (PSC) and Inflammatory Bowel Disease (IBD): A Condition Exemplifying the Crosstalk of the Gut–Liver Axis

[Experimental & Molecular Medicine] Given the high risk of malignancies associated with PSC-IBD, it is critical to identify patients at high risk and implement appropriate surveillance and monitoring strategies. The authors provide an overview of PSC-IBD, which exemplifies the gut–liver axis.

Immunology of Human Fibrosis

[Nature Immunology] Scientists review recent advances in the understanding of the fibrotic microenvironment in human diseases, with a focus on immune cell profiles and functional immune–stromal interactions.

Advances in Biomimetic Hydrogels for Organoid Culture

[Chemical Communications] Investigators introduce the challenge of animal-derived decellularised extracellular matrices in organoid culture, and summarize the categories of biomimetic hydrogels currently used for organoid culture.

Human Trophoblast Stem Cell-State Acquisition from Pluripotent Stem Cells and Somatic Cells

[Current Opinion in Genetics & Development] The authors summarize recent advances in derivation of human trophoblast stem cells (hTSCs), with a focus on derivation from naive and primed hPSCs, as well as via reprogramming of somatic cells into induced hTSCs.

Targeting Cancer Stem Cells as a Strategy for Reducing Chemotherapy Resistance in Head and Neck Cancers

[Journal Of Cancer Research And Clinical Oncology] Head and neck cancer cells belonging to the stem cell population are distinguished by the high expression of certain surface proteins (e.g., CD10, CD44, CD133), pluripotency-related transcription factors (SOX2, OCT4, NANOG), and increased activity of aldehyde dehydrogenase (ALDH). Chemotherapy itself increases the percentage of stem-like cells.

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