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Intrapancreatic Fat, Pancreatitis, and Pancreatic Cancer

[Cellular And Molecular Life Sciences] An extensive review of studies addressing the accumulation and activity of intrapancreatic adipocytes in the pancreas (IPAs) reveals that an unexpectedly diverse group of factors cause replacement of acinar tissue with IPAs, particularly in the mouse models that are essential tools for research into pancreatic cancer.

Resistance to Immune Checkpoint Therapies by Tumour-Induced T Cell Desertification and Exclusion: Key Mechanisms, Prognostication, and New Therapeutic Opportunities

[British Journal of Cancer] The authors dive into critical mechanisms by which cancer cells induce T cell ‘desertification’ and ‘exclusion’ in immune checkpoint therapies refractory tumors.

Human Neutrophil Fc Gamma Receptors: Different Buttons for Different Responses

[Journal of Leukocyte Biology] Investigators describe the major Fcγ receptors expressed on human neutrophils and discuss how each Fcγ receptor activates a choice of signaling pathways to stimulate particular neutrophil responses.

Insight on Immune Cells in Rejection and Infection Postlung Transplant

[Immunity Inflammation And Disease] Scientists provide a concise overview of the role of immune cells in rejection and infection after lung transplantation.

Updates in Hematopoietic Cell Transplant and Cellular Therapies That Enhance the Risk for Opportunistic Infections

[Transplant Infectious Disease] The authors update the infectious disease physician on newer advances in hematopoietic ell transplant and cellular therapy, including haploidentical transplant, expanding indications for transplant in older individuals and children, and chimeric antigen receptor T cells.

Are We Ready for Personalized CAR-T Therapy?

[European Journal Of Haematology] The authors outline the need for an individualized approach to CAR-T therapy, presents the lights and shadows of currently available drugs and try to predict the nearest perspective.

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