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Engineering Considerations of iPSC-Based Personalized Medicine

[Biomaterials Research] The authors summarize how engineering strategies have been used to advance iPSC-based personalized medicine by categorizing the development process into three distinctive steps.

The Immunology of Long COVID

[Nature Reviews Immunology] Scientists focus on current thinking about the pathophysiology of long COVID and the evidence for potential underpinning mechanisms.

Mesenchymal Stem Cells: Their Role in the Tumor Microenvironment

[Tissue Engineering Part B-Reviews] It has been described that MSCs can be activated and present various phenotypes, which could explain the divergence in their action; however, these activation mechanisms and the different phenotypes still need to be well known.

Crosstalk Between Autophagy and CSCs: Molecular Mechanisms and Translational Implications

[Cell Death & Disease] It has been found that autophagy can contribute to the maintenance of CSC stemness, facilitate the tumor cells adapt to changes in the microenvironment, and promote tumor survival, whereas in some other cases autophagy acts as an important process involved in the deprivation of CSC stemness thus leading to tumor death.

Molecular Regulation and Therapeutic Implications of Cell Death in Pulmonary Hypertension

[Cell Death Discovery] The authors provide a summary of the regulatory patterns of different programmed cell death (PCD) modes and their potential effects on pulmonary hypertension. Additionally, they describes the current understanding of this complex and interconnected process and analyzes the therapeutic potential of targeting specific PCD modes as molecular targets.

Secretome-Based Acellular Therapy of Bone Marrow-Derived Mesenchymal Stem Cells in Degenerative and Immunological Disorders: A Narrative Review

[Heliyon] Investigators review the diverse bioactive molecules of secretomes that successfully treat inflammatory and degenerative diseases of the musculoskeletal, cardiovascular, nervous, respiratory, reproductive, gastrointestinal, and anti-aging systems.

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