The Immunology of Asymptomatic SARS-CoV-2 Infection: What Are the Key Questions?

An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission. Areas that need greater clarity include the extent to which asymptomatic disease leads to persistent symptoms, and the quality, quantity and durability of immune priming required to confer subsequent protection.
[Nature Reviews Immunology]
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Chitosan as Possible Inhibitory Agents and Delivery Systems in Leukemia

The authors take a look at the latest advances in the use of chitosan in the treatment and improvement of leukemia.
[Cancer Cell International]
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The Manipulation of Apoptosis for Cancer Therapy Using BH3-Mimetic Drugs

Investigators outline the current state of BH3-mimetic drugs targeting various prosurvival BCL-2 family proteins and discuss emerging data regarding primary and acquired resistance to these agents and approaches that may overcome this.
[Nature Reviews Cancer]
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The Physiological Role of β-Cell Heterogeneity in Pancreatic Islet Function

The focus of this Review is the description of how endocrine cell heterogeneity affects the regulation of hormone secretion within the islets of Langerhans.
[Nature Reviews Endocrinology]
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Dissecting the Relationship between Antimicrobial Peptides and Mesenchymal Stem Cells

The authors discuss the production of antimicrobial peptides by MSCs, revise the multiple functions of these peptides, including their influence over MSCs, and present an overview of clinical situations in which the antimicrobial properties of MSCs may be explored for therapy.
[Pharmacology & Therapeutics]
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Platelet-Mediated Tumor Metastasis Mechanism and the Role of Cell Adhesion Molecules

Investigators introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules in it.
[Critical Reviews in Oncology/Hematology]
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Potential Influence of the Microbiome Environment in Patients with Biliary Tract Cancer and Implications for Therapy

Scientists summarize the available evidence on the microbiome environment in patients with biliary tract cancer, including a discussion around confounding factors, implications for therapy and proposed future directions.
[British Journal of Cancer]
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Combining Systemic and Locally Applied Cellular Therapies for the Treatment of Systemic Sclerosis

Investigators provide an overview of the cellular therapies available for the management of systemic sclerosis, including systemically injected therapies and locally administered regenerative cell therapies.
[Bone Marrow Transplantation]
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The Emerging Role of Off-the-Shelf Engineered Natural Killer Cells in Targeted Cancer Immunotherapy

CAR-engineered natural killer (NK)-92 cells have demonstrated robust antitumor activity in in vitro and in vivo preclinical studies, propelling the clinical development of CAR NK-92 cells.
[Molecular Therapy-Oncolytics]
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Organoids in Image-Based Phenotypic Chemical Screens

Organoids hold great potential for high-content screening because they recapitulate many aspects of parent tissues and can be derived from patient material.
[Experimental & Molecular Medicine]
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Gene-Editing, Immunological and iPSCs Based Therapeutics for Muscular Dystrophy

The authors summarize gene-editing, immunological and induced pluripotent stem cell based therapeutics for muscular dystrophy treatment.
[European Journal of Pharmacology]
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