Tumor Microenvironment and Immune-Related Therapies of Head and Neck Squamous Cell Carcinoma

Investigators discuss classical head and neck squamous cell carcinoma immunotherapy, and highlight examples of clinical trials using CTLA-4 inhibitors and PD-1/PD-L1 related combination therapies.
[Molecular Therapy-Oncolytics]
Qin, Y., Zheng, X., Gao, W., Wang, B., & Wu, Y. (2021). Tumor microenvironment and immune-related therapies of Head and neck squamous cell carcinoma. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.01.011 Cite
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Recent Advances and Discoveries in the Mechanisms and Functions of CAR T Cells

The authors discuss the major advances and changes made over the past three years to our understanding of chimeric antigen receptor T cell efficacy and safety.
[Nature Reviews Cancer]
Larson, R. C., & Maus, M. V. (2021). Recent advances and discoveries in the mechanisms and functions of CAR T cells. Nature Reviews Cancer, 1–17. https://doi.org/10.1038/s41568-020-00323-z Cite
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CRISPR Technologies and the Search for the PAM-Free Nuclease

Scientists review ongoing efforts toward realizing protospacer adjacent motif-free nucleases through natural ortholog mining and protein engineering.
[Nature Communications]
Collias, D., & Beisel, C. L. (2021). CRISPR technologies and the search for the PAM-free nuclease. Nature Communications, 12(1), 555. https://doi.org/10.1038/s41467-020-20633-y Cite
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COVID-19 Vaccines: Where We Stand and Challenges Ahead

Tt remains to be elucidated whether and to what extent the capacity of vaccines under evaluation and of unrelated vaccines such as BCG can increase immunological fitness by training innate immunity to SARS-CoV-2 and pathogen-agnostic protection.
[Cell Death & Differentiation]
Forni, G., & Mantovani, A. (2021). COVID-19 vaccines: where we stand and challenges ahead. Cell Death & Differentiation, 1–14. https://doi.org/10.1038/s41418-020-00720-9 Cite
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Targeting the Ubiquitination/Deubiquitination Process To Regulate Immune Checkpoint Pathways

Scientists summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity, and discuss therapeutic significance of targeting ubiquitination/deubiquitination pathways in the future of immunotherapy.
[Signal Transduction and Targeted Therapy]
Liu, J., Cheng, Y., Zheng, M., Yuan, B., Wang, Z., Li, X., Yin, J., Ye, M., & Song, Y. (2021). Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways. Signal Transduction and Targeted Therapy, 6(1), 1–11. https://doi.org/10.1038/s41392-020-00418-x Cite
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Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes

The authors discuss the roles of lncRNAs in type 2 diabetes (T2D) and cardiovascular disease (CVD) conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.
[Diagnostics]
Ismail, N., Abdullah, N., Abdul Murad, N. A., Jamal, R., & Sulaiman, S. A. (2021). Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes. Diagnostics, 11(1), 145. https://doi.org/10.3390/diagnostics11010145 Cite
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The Anti-Skin Squamous Cell Carcinoma Cell Activity by the SphK1-Targeting microRNA-6784

The authors identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). They showed that miR-6784 was located at the cytoplasm of A431 skin squamous cell carcinoma cells.
[Aging]
Aging | The anti-skin squamous cell carcinoma cell activity by the SphK1-targeting microRNA-6784 - Full Text. (n.d.). Retrieved January 22, 2021, from https://www.aging-us.com/article/202336/text Cite
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Differences of Embedding Adipose-Derived Stromal Cells in Natural and Synthetic Scaffolds for Dermal and Subcutaneous Delivery

Scientists investigate the trends in injectable scaffolds for adipose-derived stromal cell (ASC) delivery in the dermis, and injectable or implantable scaffolds for ASC delivery in the subcutis.
[Stem Cell Research & Therapy]
Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved January 23, 2021, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02132-5 Cite
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Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review

Scientists assessed the current literature detailing the effects of ω-3 polyunsaturated fatty acids (PUFAs) on epithelial cells. Marine-derived ω-3 PUFAs, eicosapentanoic acid and docosahexanoic acid, as well as plant-derived alpha-linolenic acid, are incorporated into intestinal epithelial cell membranes, prevent changes to epithelial permeability, inhibit the production of pro-inflammatory cytokines and eicosanoids and induce the production of anti-inflammatory eicosanoids and docosanoids.
[Foods]
Durkin, L. A., Childs, C. E., & Calder, P. C. (2021). Omega-3 Polyunsaturated Fatty Acids and the Intestinal Epithelium—A Review. Foods, 10(1), 199. https://doi.org/10.3390/foods10010199 Cite
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Immunotherapy and Immunotherapy Combinations in Metastatic Castration-Resistant Prostate Cancer

The authors review promising immunotherapies in development and ongoing trials for metastatic castration-resistant prostate cancer (mCRPC). These novel trials will build on past experiences and promise to usher a new era to treat patients with mCRPC.
[Cancers]
Bansal, D., Reimers, M. A., Knoche, E. M., & Pachynski, R. K. (2021). Immunotherapy and Immunotherapy Combinations in Metastatic Castration-Resistant Prostate Cancer. Cancers, 13(2), 334. https://doi.org/10.3390/cancers13020334 Cite
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Adult Tissue-Resident Stem Cells—Fact or Fiction?

It has proved difficult to isolate quiescent stem cells as a physical entity. Recent single-cell RNAseq studies on several adult tissues including ovary, prostate, and cardiac tissues have not been able to detect stem cells. Thus, it has been postulated that adult cells dedifferentiate to stem-like state to ensure regeneration and can be defined as cells capable to replace lost cells through mitosis.
[Stem Cell Research & Therapy]
Bhartiya, D. (2021). Adult tissue-resident stem cells—fact or fiction? Stem Cell Research & Therapy, 12(1), 73. https://doi.org/10.1186/s13287-021-02142-x Cite
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