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Review

Integrating Single-Cell Multi-Omics and Prior Biological Knowledge for a Functional Characterization of the Immune System

[Nature Immunology] The authors review how the integration of single-cell and spatial multi-omics data with prior knowledge allows us to obtain functional insights, focusing on gene regulatory processes and cell–cell interactions.

The Benefits of Stem Cell Biology and Tissue Engineering in Low-Earth Orbit

[Stem Cells And Development] Investigators underscore the potential benefits of microgravity on fundamental stem cell properties, highlighting the adaptability of cells to their environment and emphasizing physical stimuli as a key factor influencing cultured cells.

Efficacy of Growth Factor Gene–Modified Stem Cells for Motor Function After Spinal Cord Injury in Rodents: A Systematic Review and Meta-Analysis

[Neurosurgical Review] Scientists evaluated the effectiveness of growth factor gene–modified stem cells in restoring motor function after spinal cord injury. Two reviewers searched four databases, including PubMed, Embase, Web of Science, and Scopus, to identify relevant records.

Mineralized Collagen Scaffolds for Regenerative Engineering Applications

[Current Opinion In Biotechnology] Scientists summarize key considerations regarding the current state-of-the-art design and use of collagen biomaterials for tissue engineering applications.

HDAC Inhibitors as Pharmacological Treatment for Duchenne Muscular Dystrophy: A Discovery Journey from Bench to Patients

[Trends in Molecular Medicine] Scientists describe the molecular, preclinical, and clinical evidence supporting the efficacy of histone deacetylase (HDAC) inhibitors in countering disease progression by targeting pathogenic networks of gene expression in multiple muscle-resident cell types of patients with Duchenne muscular dystrophy.

Leukemogenesis Occurs in a Microenvironment Enriched by Extracellular Microvesicles/Exosomes: Recent Discoveries and Questions to Be Answered

[Leukemia] Leukemogenesis occurs and progresses in extracellular microvesicles enriched microenvironments. The authors present a current point of view on this topic and review some selected most recent discoveries and papers.

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