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Young-Onset Colorectal Cancer

[Nature Reviews Disease Primers] To better understand the underlying mechanism and define relationships between environmental factors and young-onset-colorectal cancer development, long-term prospective studies are needed with lifestyle data collected from childhood.

Crosstalk between Colorectal Cancer Cells and Cancer-Associated Fibroblasts in the Tumor Microenvironment Mediated by Exosomal Noncoding RNAs

[Frontiers in Immunology] The authors review the current status and progress of research on cancer-associated fibroblastss-derived exosomal non-coding RNAs in colorectal cancer.

Insight into Immune Checkpoint Inhibitor Therapy for Colorectal Cancer from the Perspective of Circadian Clocks

[Immunology] Scientists highlight the crosstalk between the tumor immune microenvironment in colorectal cancer (CRC) and the immunogenicity of CRC cells based on the circadian clocks.

Human Pluripotent-Stem-Cell-Derived Organoids for Drug Discovery and Evaluation

[Cell Stem Cell] The authors provide an overview of the achievements and challenges in using hPSC-derived organoids to conduct relevant high-throughput, high-contentscreens and drug evaluation.

Exploring the Anti-Cancer Potential of Dietary Phytochemicals for the Patients with Breast Cancer: A Comprehensive Review

[Cancer Medicine] Several issues, that is, high cost, toxicity, allergic reactions, less efficacy, multidrug resistance, and the economic cost of conventional anti-cancer therapies, has prompted scientists to discover innovative approaches and new chemo-preventive agents.

The Role of DNA Hydroxymethylation and TET Enzymes in Placental Development and Pregnancy Outcome

[Clinical Epigenetics] Investigators focus on DNA hydroxymethylation and its epigenetic regulators in human and mouse placental development and function.

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