Review

[Signal Transduction And Targeted Therapy] Investigators discuss the changes in irradiated cancer cells and immune cells in the tumor microenvironment under different radiotherapy (RT) regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT.

[Nature Reviews Bioengineering] The authors outline key challenges in renal replacement and examine the clinical potential, current limitations and ethical considerations of bioengineering approaches aimed at replacing renal function, including kidney decellularization and recellularization.

[Hepatology] The authors critically discuss the particularities in the management of patients with non-alcoholic fatty liver disease (NAFLD)-related cirrhosis.

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors present a systematic overview of biogenesis and down streaming molecular mechanism of the subgroups of non-coding RNAs (ncRNAs). They also explain ncRNA-based strategies and challenges to target the chemo-, radio-, and immunoresistance in TNBCs from a clinical standpoint.

[Pharmacology & Therapeutics] The complexity of the regulation of vascular fibrosis and stiffening in pulmonary hypertension allows the exploration of numerous potential therapeutic interventions.

[Physiological Reviews] Scientists provide an overview of placental development and highlight the instructional role of the epigenome in dictating cell fate decisions specifically in the placental trophoblast cell lineage.