Review

[Critical Reviews In Oncology/Hematology] Scientists discuss the current immunotherapeutic regimens used to treat malignant melanoma, the molecular and cellular mechanisms involved, and current clinical studies that have investigated the use, efficacy, and adverse events of immunotherapy in melanoma.

[Cell Stem Cell] The authors examine how the ability to generate diverse central nervous system cell types from stem cells, along with a deeper understanding of cell-type-specific functions and pathology, is advancing preclinical development of cell products for the treatment of neurodegenerative diseases.

[Transplantation And Cellular Therapy] Focusing on both large B-cell lymphoma and multiple myeloma, investigators review resistance mechanisms, explore therapeutic avenues to overcome resistance to CAR T-cell therapies, and discuss the management of patients who have relapsed after CAR T-cell therapy.

[Stem Cell Research & Therapy] The authors highlight recent advances in muscle tissue engineering with a focus on recent strategies related to the regulation of vascularization and immune system response at the site of injury.

[European Respiratory Review] Investigators present a schematic that illustrates the role of ncRNAs in pathophysiological changes to ASMCs that may be useful in future research in diagnostic and treatment strategies for patients with asthma.

[Advanced Materials] The authors highlight challenges in recapitulating the biological complexity seen in bone and how synergistic application of dynamic hydrogels and innovative bioprinting pipelines could address these challenges to achieve bone models.