Investigators highlight recent strategies to improve chimeric antigen therapy (CAR)-T cell therapy by engineering the CAR protein, T cells, and the interaction between T cells and other components in the tumor microenvironment.
Pulmonary toxicity from taxanes presents as an ILD‐type reaction characterized by increasing dyspnoea, dry cough, fever and bilateral pulmonary interstitial infiltrates.
The authors describe the molecular regulation of lysosome biogenesis and detail the emerging anabolic roles of the lysosome in skeletal muscle with particular emphasis on how these roles may mediate adaptations to chronic resistance exercise.
[American Journal of Physiology-Cell Physiology]
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The authors discuss the current knowledge of aryl hydrocarbon receptors mediation on endothelial function and potential mechanisms underlying these actions with a focus on placental endothelial cells.
[Biology of Reproduction]
Reports of widespread thromboses and disseminated intravascular coagulation in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. This perspective has critical implications for treatment.
[Nature Reviews Rheumatology]
Many different groups have modified autologous diabetic endothelial-colony-forming cells to improve their function using a variety of methods including pre-treatment with different factors or with genetic modification.
Renal cell carcinoma is considered to be an immunogenic tumor but is known to mediate immune dysfunction in large part by eliciting the infiltration of immune-inhibitory cells, such as regulatory T cells and myeloid-derived suppressor cells, into the tumor microenvironment.
[Nature Reviews Nephrology]
The authors document the well‐known miR‐SNPs that are known to be associated with breast cancer. Two principals are discussed: (a) SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; (b) changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.
[Journal of Cellular Physiology]
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Scientists provide an analysis on how ribosomes translate cancer progression with a final focus on the ribosomal receptor for activated C kinase 1 (RACK1) in breast cancer.
[British Journal of Pharmacology]
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The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
[Seminars in Cell & Developmental Biology]
The authors introduce SOX2 as a transcription factor, its domain structure, normal physiological functions, and its involvement in human cancers. They next discuss its role in embryonic development and stem cell-renewal.
[Signal Transduction and Targeted Therapy]
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In this review, the authors summarize the updated knowledge, perspectives, and limitations of PSC-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology]