The authors cast a new, medically oriented light on hypothalamic neuroanatomy and contribute to a better understanding of the mechanisms responsible for neuropeptide-related physiology and the nature of possible neuroendocrinal interactions between local regulatory pathways.
[Journal of Chemical Neuroanatomy]
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The authors discuss the three currently licensed therapies for spinal muscular atrophy, briefly highlighting their respective advantages and disadvantages, before considering alternative approaches to increasing survival motor neuron protein levels.
[Cell Reports Medicine]
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Scientists summarize the diverse processes underlying resistance to poly(ADP-ribose) polymerase (PARP) inhibitors and discuss the potential strategies that might overcome these mechanisms such as combinations with chemotherapies, targeting the acquired vulnerabilities associated with resistance to PARP inhibitors or suppressing genomic instability.
[Nature Reviews Clinical Oncology]
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Recent studies describe potential diagnostic and therapeutic applications of the microbiome, but further clinical investigation is needed. The authors explore the existing literature on the discovery of the human microbiome and its relationship to prostate cancer.
[Prostate Cancer and Prostatic Diseases]
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Researchers discussed the intracellular signal events contributing to pancreatic myofibroblasts activation, and crosstalk with different components of tumor microenvironment.
[Journal of Gastroenterology]
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The rationale and early immunobiology of CD40 as a master regulator of dendritic cell activation is reviewed, with further contextualization and appreciation for the role of CD40 stimulation not only in cancer vaccines but also in other contemporary immune-oncology approaches.
[Cellular & Molecular Immunology]
Scientists discuss the experimental evidence reported in recent years linking erythropoietin (Epo) and central nervous system function through investigations aimed at finding benefits in the treatment of neurodegenerative diseases and review the proposed mechanisms for novel derivatives which may improve the neuroprotective action of Epo.
[Journal of Neurochemistry]
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The authors review the development of anticancer drugs targeting cancer-specific functional therapeutic targets, namely, maternal embryonic leucine zipper kinase, T-lymphokine-activated killer cell-originated protein kinase, and brefeldin A-inhibited guanine nucleotide-exchange protein 3, as identified through comprehensive breast cancer transcriptomics.
[Journal of Human Genetics]
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Investigators review the current progress targeting different immune checkpoints in several-lines treatment for TNBC, including programmed death-1/programmed death ligand-1 inhibitors, cytotoxic T-lymphocyte associated antigen-4 inhibitor, and other novel immunotherapeutic approaches.
[Biochimica et Biophysica Acta-Reviews On Cancer]
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MSCs, a kind of multipotent stem cells with self-renewal ability and multi-differentiation ability, have become the “practical stem cells” for the treatment of diseases.
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Scientists provide a rundown of the rapidly expanding toolbox for CRISPR-based diagnostics, in particular the various assays, preamplification strategies and readouts, and highlight their main applications in the sensing of a wide range of molecular targets relevant to human health.
[Nature Biomedical Engineering]