Engineering CAR-T Cells for Next-Generation Cancer Therapy

Investigators highlight recent strategies to improve chimeric antigen therapy (CAR)-T cell therapy by engineering the CAR protein, T cells, and the interaction between T cells and other components in the tumor microenvironment.
[Cancer Cell]
Hong, M., Clubb, J. D., & Chen, Y. Y. (2020). Engineering CAR-T Cells for Next-Generation Cancer Therapy. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.07.005 Cite
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Pulmonary Toxicity of Systemic Lung Cancer Therapy

Pulmonary toxicity from taxanes presents as an ILD‐type reaction characterized by increasing dyspnoea, dry cough, fever and bilateral pulmonary interstitial infiltrates.
[Respirology]
Long, K., & Suresh, K. (n.d.). Pulmonary toxicity of systemic lung cancer therapy. Respirology, n/a(n/a). https://doi.org/10.1111/resp.13915 Cite
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More than Just a Garbage Can: Emerging Roles of the Lysosome as an Anabolic Organelle in Skeletal Muscle

The authors describe the molecular regulation of lysosome biogenesis and detail the emerging anabolic roles of the lysosome in skeletal muscle with particular emphasis on how these roles may mediate adaptations to chronic resistance exercise.
[American Journal of Physiology-Cell Physiology]
Abou Sawan, S., Mazzulla, M., Moore, D. R., & Hodson, N. (2020). More than just a garbage can: emerging roles of the lysosome as an anabolic organelle in skeletal muscle. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00241.2020 Cite
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Roles of Aryl Hydrocarbon Receptor in Endothelial Angiogenic Responses

The authors discuss the current knowledge of aryl hydrocarbon receptors mediation on endothelial function and potential mechanisms underlying these actions with a focus on placental endothelial cells.
[Biology of Reproduction]
Li, Y., Zhou, C., Lei, W., Wang, K., & Zheng, J. (n.d.). Roles of Aryl Hydrocarbon Receptor in Endothelial Angiogenic Responses†. Biology of Reproduction. https://doi.org/10.1093/biolre/ioaa128 Cite
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Emerging Evidence of a COVID-19 Thrombotic Syndrome Has Treatment Implications

Reports of widespread thromboses and disseminated intravascular coagulation in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. This perspective has critical implications for treatment.
[Nature Reviews Rheumatology]
Merrill, J. T., Erkan, D., Winakur, J., & James, J. A. (2020). Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications. Nature Reviews Rheumatology, 1–9. https://doi.org/10.1038/s41584-020-0474-5 Cite
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The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus

Many different groups have modified autologous diabetic endothelial-colony-forming cells to improve their function using a variety of methods including pre-treatment with different factors or with genetic modification.
[Cells]
Lyons, C. J., & O’Brien, T. (2020). The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus. Cells, 9(7), 1731. https://doi.org/10.3390/cells9071731 Cite
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The Immunology of Renal Cell Carcinoma

Renal cell carcinoma is considered to be an immunogenic tumor but is known to mediate immune dysfunction in large part by eliciting the infiltration of immune-inhibitory cells, such as regulatory T cells and myeloid-derived suppressor cells, into the tumor microenvironment.
[Nature Reviews Nephrology]
Díaz-Montero, C. M., Rini, B. I., & Finke, J. H. (2020). The immunology of renal cell carcinoma. Nature Reviews Nephrology, 1–15. https://doi.org/10.1038/s41581-020-0316-3 Cite
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MicroRNA‐Related Single‐Nucleotide Polymorphisms and Breast Cancer

The authors document the well‐known miR‐SNPs that are known to be associated with breast cancer. Two principals are discussed: (a) SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; (b) changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.
[Journal of Cellular Physiology]
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Ribosomes as Nexus between Translation and Cancer Progression: Focus on Ribosomal RACK1 in Breast Cancer

Scientists provide an analysis on how ribosomes translate cancer progression with a final focus on the ribosomal receptor for activated C kinase 1 (RACK1) in breast cancer.
[British Journal of Pharmacology]
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Taming Human Brain Organoids One Cell at a Time

The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
[Seminars in Cell & Developmental Biology]
Atamian, A., Cordón-Barris, L., & Quadrato, G. (2020). Taming human brain organoids one cell at a time. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.05.022 Cite
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Functional Characterization of SOX2 as an Anticancer Target

The authors introduce SOX2 as a transcription factor, its domain structure, normal physiological functions, and its involvement in human cancers. They next discuss its role in embryonic development and stem cell-renewal.
[Signal Transduction and Targeted Therapy]
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Heart Regeneration Using Pluripotent Stem Cells

In this review, the authors summarize the updated knowledge, perspectives, and limitations of PSC-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology]
Kadota, S., Tanaka, Y., & Shiba, Y. (2020). Heart regeneration using pluripotent stem cells. Journal of Cardiology, 0(0). https://doi.org/10.1016/j.jjcc.2020.03.013 Cite
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