The Improbable Targeted Therapy: KRAS as an Emerging Target in Non-Small Cell Lung Cancer (NSCLC)

The authors review promising therapeutics tested for KRAS mutant non-small cell lung cancer.
[Cell Reports Medicine]
Salgia, R., Pharaon, R., Mambetsariev, I., Nam, A., & Sattler, M. (2021). The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC). Cell Reports Medicine, 2(1). https://doi.org/10.1016/j.xcrm.2020.100186 Cite
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Liquid Biopsy Enters the Clinic – Implementation Issues and Future Challenges

The authors discuss key issues and gaps in technology, clinical trial methodologies and logistics for the eventual integration of liquid biopsy into the clinical workflow.
[Nature Reviews Clinical Oncology]
Ignatiadis, M., Sledge, G. W., & Jeffrey, S. S. (2021). Liquid biopsy enters the clinic — implementation issues and future challenges. Nature Reviews Clinical Oncology, 1–16. https://doi.org/10.1038/s41571-020-00457-x Cite
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MicroRNA Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

Investigators summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
Niu, T., Zhang, W., & Xiao, W. (2021). MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer. Cancer Cell International, 21(1), 31. https://doi.org/10.1186/s12935-020-01716-8 Cite
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Amniotic Fluid Stem Cells as a Novel Strategy for the Treatment of Fetal and Neonatal Neurological Diseases

Investigators outline the results of preclinical research on fetal stem cell therapy, mainly involving human amniotic fluid stem cells, in the context of perinatal neurological diseases.
[Placenta]
Abe, Y., Ochiai, D., Sato, Y., Otani, T., Fukutake, M., Ikenoue, S., Kasuga, Y., & Tanaka, M. (2021). Amniotic fluid stem cells as a novel strategy for the treatment of fetal and neonatal neurological diseases. Placenta, 104, 247–252. https://doi.org/10.1016/j.placenta.2021.01.009 Cite
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The Renaissance of Chemically Generated Bispecific Antibodies

Investigators review chemical methods for the generation of bsAbs, showing that the newest examples of these techniques are worthy competitors to the industry-standard expression-based strategies.
[Nature Reviews Chemistry]
Szijj, P., & Chudasama, V. (2021). The renaissance of chemically generated bispecific antibodies. Nature Reviews Chemistry, 1–15. https://doi.org/10.1038/s41570-020-00241-6 Cite
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Beyond Horizontal Gene Transfer: The Role of Plasmids in Bacterial Evolution

Scientists discuss recent advances that underscore the importance of plasmids in bacterial ecology and evolution beyond horizontal gene transfer.
[Nature Reviews Microbiology]
Rodríguez-Beltrán, J., DelaFuente, J., León-Sampedro, R., MacLean, R. C., & San Millán, Á. (2021). Beyond horizontal gene transfer: the role of plasmids in bacterial evolution. Nature Reviews Microbiology, 1–13. https://doi.org/10.1038/s41579-020-00497-1 Cite
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The BET Family in Immunity and Disease

Scientists cover the accumulating data about the roles of the BET family in innate immunity, and discuss the attractive prospect of manipulating the BET family as a new treatment for disease.
[Signal Transduction and Targeted Therapy]
Wang, N., Wu, R., Tang, D., & Kang, R. (2021). The BET family in immunity and disease. Signal Transduction and Targeted Therapy, 6(1), 1–22. https://doi.org/10.1038/s41392-020-00384-4 Cite
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Targeting Cancer-Promoting Inflammation — Have Anti-Inflammatory Therapies Come of Age?

The authors review the current clinical advances and experimental findings supporting the utility of an anti-inflammatory approach to the treatment of solid malignancies.
[Nature Reviews Clinical Oncology]
Hou, J., Karin, M., & Sun, B. (2021). Targeting cancer-promoting inflammation — have anti-inflammatory therapies come of age? Nature Reviews Clinical Oncology, 1–19. https://doi.org/10.1038/s41571-020-00459-9 Cite
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Advances in CNS Organoids: A Focus on Organoid-Based Models for Motor Neuron Disease

Scientists review recent advances in the development of CNS organoid models, their application in neurodegenerative diseases and technical limitations.
[Tissue Engineering Part C: Methods]
Vieira de Sa, R., Canizares Luna, M., & Pasterkamp, J. (2021). Advances in CNS organoids: a focus on organoid-based models for motor neuron disease. Tissue Engineering Part C: Methods. https://doi.org/10.1089/ten.TEC.2020.0337 Cite
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Overcoming the Challenges Associated with CD3+ T-Cell Redirection in Cancer

The authors discuss novel approaches to overcome the key challenges associated with CD3+ bispecific T-cell redirection in order to achieve an optimal balance of anti-tumour activity and safety.
[British Journal of Cancer]
Singh, A., Dees, S., & Grewal, I. S. (2021). Overcoming the challenges associated with CD3+ T-cell redirection in cancer. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01225-5 Cite
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Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Niemann-Pick Type C1

Scientists present a review focusing on studies that have used iPSCs for disease modeling and drug discovery in NPC1 and draw a comparison to commonly used NPC1 models.
[International Journal of Molecular Sciences]
Völkner, C., Liedtke, M., Hermann, A., & Frech, M. J. (2021). Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Niemann-Pick Type C1. International Journal of Molecular Sciences, 22(2), 710. https://doi.org/10.3390/ijms22020710 Cite
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