Inhibiting Microcephaly Genes as Alternative to Microtubule Targeting Agents to Treat Brain Tumors

The genes mutated in primary hereditary microcephaly are ubiquitously expressed in proliferating cells, but under normal conditions are selectively required during brain development, in neural progenitors.
[Cell Death & Disease]
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Lung Neuroendocrine Neoplasms: Recent Progress and Persistent Challenges

The author summarizes key recent developments relevant to the pathologic diagnosis of lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma, and large cell neuroendocrine carcinoma.
[Modern Pathology]
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Biobanking of Human Gut Organoids for Translational Research

Focusing on human intestinal organoids, researcher highlight some of the key aspects that need to be considered and provide an outlook for future development in this exciting field.
[Environmental and Molecular Mutagenesis]
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Gastrointestinal Cancer Organoids—Applications in Basic and Translational Cancer Research

Scientists describe different gastrointestinal organoid methodologies and their applications for basic and translational cancer research.
[Environmental and Molecular Mutagenesis]
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3D Tumor Angiogenesis Models: Recent Advances and Challenges

Scientists summarize recent advancements of 3D tumor vascular model systems which include tissue engineering-based tumor models; vascular organoid models, and organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.
[Journal of Cancer Research and Clinical Oncology]
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Nutraceuticals and Their Role in Tumor Angiogenesis

The literature concerning the pro-angiogenic and/or anti-angiogenic nutraceuticals and the possible activated pathways in cancer and other non-neoplastic diseases by in vivo and in vitro experiments are reviewed.
[Experimental Cell Research]
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Control of Host Mitochondria by Bacterial Pathogens

The authors discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.
[Trends in Microbiology]
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Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

Recent advances in bioinspired delivery platforms for cancer vaccines, existing obstacles faced, as well as insights and future directions for the field are discussed.
[Advanced Materials]
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Current Status of Organoid Culture in Urological Malignancy

The authors summarize the development and applications of three-dimensional organoid cultures in urological cancers, mainly focusing on prostate, urinary bladder and kidney cancers, and assess the future prospects of this model.
[International Journal of Urology]
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Building and Maintaining the Skin

Investigators review diverse cellular interactions and highlight how far-reaching signals can be transmitted at the local level to enable skin stem cells to tailor their actions to suit the particular occasion and optimize fitness.
[Cold Spring Harbor Perspectives in Biology]
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Insight into the Role of Dermal White Adipose Tissue Loss in Dermal Fibrosis

The authors indicate that the adipocytes-to-myofibroblasts transition in dermal white adipose tissue reflects the direct contribution to the dermal fibrosis formation
[Journal of Cellular Physiology]
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