How to Turn Up the Heat on the Cold Immune Microenvironment of Metastatic Prostate Cancer

The authors discuss the immunopathology of the prostate tumor microenvironment, strategies for treating prostate cancer with immunotherapies, and a perspective on potential approaches to enhancing the efficacy of immunotherapies.
[Prostate Cancer and Prostatic Diseases]
Stultz, J., & Fong, L. (2021). How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer. Prostate Cancer and Prostatic Diseases, 1–21. https://doi.org/10.1038/s41391-021-00340-5 Cite
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Optimizing the Diagnosis and Management of Ductal Prostate Cancer

Although current understanding of the biology of ductal adenocarcinoma is limited, genomic analyses have provided insights into the pathology behind its aggressive behavior and potential future therapeutic targets.
[Nature Reviews Urology]
Optimizing the diagnosis and management of ductal prostate cancer | Nature Reviews Urology. (n.d.). Retrieved April 8, 2021, from https://www.nature.com/articles/s41585-021-00447-3 Cite
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Induced Pluripotent Stem Cell Technology: Trends in Molecular Biology, from Genetics to Epigenetics

The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.
[Epigenomics]
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Novel Genome-Editing-Based Approaches to Treat Motor Neuron Diseases: Promises and Challenges

Scientists review genome editing approaches aimed either at correcting the disease-causing mutations or at modulating the expression of genetic modifiers, e.g. by repairing SOD1 mutations or SMN2 splicing defect, or deleting C9orf72 expanded repeats.
[Molecular Therapy]
Miccio, A., Antoniou, P., Ciura, S., & Kabashi, E. (2021). Novel genome-editing-based approaches to treat motor neuron diseases: promises and challenges. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.04.003 Cite
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Breast Cancer as an Example of Tumor Heterogeneity and Tumor Cell Plasticity during Malignant Progression

Investigators used breast cancer as an example of the origins of tumor heterogeneity and of tumor cell plasticity, as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity.
[British Journal of Cancer]
Lüönd, F., Tiede, S., & Christofori, G. (2021). Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-021-01328-7 Cite
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Cancer and Stem Cells

Researchers made an attempt to scrutinize evidences that indicate the role of stem cells in tumorigenesis and metastasis, and cancer relapse.
[Experimental Biology and Medicine]
Yin, W., Wang, J., Jiang, L., & James Kang, Y. (2021). Cancer and stem cells. Experimental Biology and Medicine, 15353702211005390. https://doi.org/10.1177/15353702211005390 Cite
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Immunological Memory in Rheumatic Inflammation — a Roadblock to Tolerance Induction

Scientists discuss a paradigm shift by suggesting that beyond these reactions, chronic inflammation is driven by imprinted, pathogenic ‘memory’ cells of the immune system.
[Nature Reviews Rheumatology]
Maschmeyer, P., Chang, H.-D., Cheng, Q., Mashreghi, M.-F., Hiepe, F., Alexander, T., & Radbruch, A. (2021). Immunological memory in rheumatic inflammation — a roadblock to tolerance induction. Nature Reviews Rheumatology, 1–15. https://doi.org/10.1038/s41584-021-00601-6 Cite
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Metabolic Control of Memory T-Cell Generation and Stemness

The authors describe the different requirements for metabolic programs and metabolism-related signaling pathways in memory T-cell development.
[Cold Spring Harbor Perspectives in Biology]
Raynor, J. L., Chapman, N. M., & Chi, H. (2021). Metabolic Control of Memory T-Cell Generation and Stemness. Cold Spring Harbor Perspectives in Biology, a037770. https://doi.org/10.1101/cshperspect.a037770 Cite
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Tumor Neoantigen Mimicry by Microbial Species in Cancer Immunotherapy

The authors outline the requirement for tumor neoantigens in successful cancer immunotherapy and draws attention to the emerging role of microbiome-mediated tumor neoantigen mimicry in determining checkpoint immunotherapy outcome.
[British Journal of Cancer]
Boesch, M., Baty, F., Rothschild, S. I., Tamm, M., Joerger, M., Früh, M., & Brutsche, M. H. (2021). Tumour neoantigen mimicry by microbial species in cancer immunotherapy. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-021-01365-2 Cite
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CRISPR Technologies for the Treatment of Duchenne Muscular Dystrophy

The authors review various therapeutic strategies that use CRISPR/Cas to correct or bypass Duchenne muscular dystrophy mutations.
[Molecular Therapy-Methods & Clinical Development]
Choi, E., & Koo, T. (2021). CRISPR Technologies for the Treatment of Duchenne Muscular Dystrophy. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.04.002 Cite
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CAR-T Cell Therapy: Current Limitations and Potential Strategies

Scientists discuss recent innovations in CAR-T cell engineering to improve clinical efficacy in both hematological malignancy and solid tumors and strategies to overcome limitations of CAR-T cell therapy in both hematological malignancy and solid tumors.
[Blood Cancer Journal]
Sterner, R. C., & Sterner, R. M. (2021). CAR-T cell therapy: current limitations and potential strategies. Blood Cancer Journal, 11(4), 1–11. https://doi.org/10.1038/s41408-021-00459-7 Cite
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