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Mechanisms of Endothelial Activation, Hypercoagulation and Thrombosis in COVID-19: A Link with Diabetes Mellitus

[Cardiovascular Diabetology] The authors provide an overview of the potential triggers of endothelial activation related to COVID-19 and COVID-19 under diabetic milieu.

Gene Therapy in Glioblastoma Multiforme: Can It Be a Role Changer?

[Heliyon] Gene therapy, a relatively nascent advanced approach, holds promise as a potential treatment for cancer, particularly glioblastoma multiforme. It possesses the potential to address the limitations of previous treatments and even newer advanced therapies like mAbs, owing to its distinct properties.

Fusion Genes in Pancreatic Tumors

[Trends In Cancer] The authors review the existing literature on the role of fusion genes in pancreatic tumors and their clinical potential as effective biomarkers and therapeutic targets.

The Regulated Cell Death at the Maternal-Fetal Interface: Beneficial or Detrimental?

[Cell Death Discovery] Investigators summarized the apoptosis, necroptosis and autophagy play both promoting and inhibiting roles in the differentiation, invasion of trophoblast, remodeling of the uterine spiral artery and decidualization, whereas ferroptosis and pyroptosis have adverse effects.

Epigenetic Underpinnings of Tumor-Immune Dynamics in Prostate Cancer Immune Suppression

[Trends In Cancer] De novo post-translational acetylation of the AR, HOXB13, and H2A at K609, K13, and K130, respectively, and phosphorylation of H4 at Y88 have emerged as key epigenetic modifications associated with castration-resistant prostate cancer.

Exploring Androgen Receptor Signaling Pathway in Prostate Cancer: A Path to New Discoveries

[International Journal Of Urology] Scientists focus on multifaceted resistance mechanisms, including androgen receptor overexpression, splice variants, missense mutations, the involvement of the glucocorticoid receptor, and alterations in coregulators and transcription factors, revealing their roles in castration-resistant prostate cancer progression.

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