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Organ-on-Chip Models for Infectious Disease Research

[Nature Microbiology] The authors review various organ-on-chip models and how they have been applied for infectious disease research. They outline the properties that make them valuable tools in microbiology, such as dynamic microenvironments, vascularization, near-physiological tissue constitutions and partial integration of functional immune cells, as well as their limitations.

Nanomaterials Boost CAR-T Therapy for Solid Tumors

[Advanced Healthcare Materials] Researchers evaluated the use of various nanomaterials in the production of CAR-T cells, genetic modification, and in vivo delivery.

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

[Cell Transplantation] Scientists review of the factors influencing the efficacy of MSCs transplantation and its association with platelet concentrates, investigating the impact of platelet concentrates’ composition, the age and health status of platelet donors, application methods, and environmental factors on the outcomes of relevant treatments.

MOFs and MOF-Based Composites as Next-Generation Materials for Wound Healing and Dressings

[Small] Metal–organic frameworks (MOF)-based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration.

Amphiphysin-2 (BIN1) Functions and Defects in Cardiac and Skeletal Muscle

[Trends in Molecular Medicine] Investigators discuss the similarities and differences in bridging integrator 1 (BIN1)’s functions in cardiac and skeletal muscle, along with its associated diseases and potential therapies.

Pulmonary Vascular Dysfunctions in Cystic Fibrosis

[Physiology] More recent research has been dedicated to elucidating the role of cystic fibrosis transmembrane conductance regulator in the endothelium. The authors summarize the current knowledge on pulmonary vascular dysfunctions in cystic fibrosis and discuss applicable therapies.

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