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Review
Human Immunology News
LAG-3, TIM-3, and TIGIT: Distinct Functions in Immune Regulation
[Immunity] The authors discuss the distinct functions of LAG-3, TIM-3, and TIGIT, including their contributions to the regulation of immune cells beyond T cells, their roles in disease, and the implications for their targeting in the clinic.
Neural Cell News
Heterogeneity and Tumoral Origin of Medulloblastoma in the Single-Cell Era
[Oncogene] The authors present an overview of the current progress in understanding of cellular heterogeneity and tumor origin of medulloblastoma and discuss novel findings in the age of single-cell technologies.
Intestinal Cell News
Challenges and Opportunities in Inflammatory Bowel Disease: From Current Therapeutic Strategies to Organoid-Based Models
[Inflammation Research] The authors highlight critical aspects of intestinal organoids in IBD, such as their potential applications, viability, cell renewal ability, and barrier functionality.
ESC & iPSC News
Pluripotent Stem Cell-Based Cardiac Regenerative Therapy for Heart Failure
[Journal Of Molecular And Cellular Cardiology] Transplantation of hPSC-cardiomyocytes (CMs) into the myocardium of large animals in a myocardial infarction model improved cardiac function. The engrafted hPSC-CMs matured, and microvessels derived from the host entered the graft abundantly.
Immunology of Infectious Disease News
Immunopathology in Human Pulmonary Tuberculosis: Inflammatory Changes in the Plasma Milieu and Impaired Host Immune Cell Functions
[Immunology] Scientists provide an overview of studies on changes in plasma milieu and discusses recent findings linking plasma factors to T cell and monocyte/macrophage pathology in pulmonary tuberculosis patients.
Immunology of Infectious Disease News
Postacute Sequelae of SARS-CoV-2 in Children
[Pediatrics] The authors provide a summary of our current knowledge about postacute sequelae of SARS-CoV-2 (PASC) in children, including prevalence, epidemiology, risk factors, clinical characteristics, underlying mechanisms, and functional outcomes, as well as a conceptual framework for PASC based on the current National Institutes of Health definition.