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Challenges and Opportunities in Inflammatory Bowel Disease: From Current Therapeutic Strategies to Organoid-Based Models

[Inflammation Research] The authors highlight critical aspects of intestinal organoids in IBD, such as their potential applications, viability, cell renewal ability, and barrier functionality.

Pluripotent Stem Cell-Based Cardiac Regenerative Therapy for Heart Failure

[Journal Of Molecular And Cellular Cardiology] Transplantation of hPSC-cardiomyocytes (CMs) into the myocardium of large animals in a myocardial infarction model improved cardiac function. The engrafted hPSC-CMs matured, and microvessels derived from the host entered the graft abundantly.

Immunopathology in Human Pulmonary Tuberculosis: Inflammatory Changes in the Plasma Milieu and Impaired Host Immune Cell Functions

[Immunology] Scientists provide an overview of studies on changes in plasma milieu and discusses recent findings linking plasma factors to T cell and monocyte/macrophage pathology in pulmonary tuberculosis patients.

Postacute Sequelae of SARS-CoV-2 in Children

[Pediatrics] The authors provide a summary of our current knowledge about postacute sequelae of SARS-CoV-2 (PASC) in children, including prevalence, epidemiology, risk factors, clinical characteristics, underlying mechanisms, and functional outcomes, as well as a conceptual framework for PASC based on the current National Institutes of Health definition.

Molecular Mechanisms in MASLD/MASH Related HCC

[Hepatology] Investigators delve into metabolic dysfunction-associated steatotic liver disease-HCC associated genetic variations and somatic mutations, disease progression and research models, multi-omics analysis, immunological and microenvironmental impacts.

Mesenchymal Stem Cell-Derived Exosomes: A Promising Alternative in the Therapy of Preeclampsia

[Stem Cell Research & Therapy] The authors elaborate on the potential therapeutic mechanism of MSC-exosomes (Exos) in treating preeclampsia, considering the main pathogenic factors of the condition, including placental vascular dysplasia, immunological disorders, and oxidative stress, based on the biological function of MSC-Exos.

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