Coronary Vessel Formation in Development and Disease: Mechanisms and Insights for Therapy

Scientists describe the latest advances in the understanding of the processes involved in coronary vessel formation, with mechanistic insights taken from developmental studies.
[Nature Reviews Cardiology]
Lupu, I.-E., De Val, S., & Smart, N. (2020). Coronary vessel formation in development and disease: mechanisms and insights for therapy. Nature Reviews Cardiology, 1–17. https://doi.org/10.1038/s41569-020-0400-1 Cite
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Hypoxia-Inducible Factor-1: A Potential Pharmacological Target to Manage Psoriasis

Scientists discuss the evidence showing the crucial role of hypoxia-inducible factor-1α in psoriasis along with interrelationship with other mediators/signaling pathways that may contribute to the development of psoriasis.
[International Immunopharmacology]
Zhu, W.-J., Li, P., Wang, L., & Xu, Y.-C. (2020). Hypoxia-inducible factor-1: A potential pharmacological target to manage psoriasis. International Immunopharmacology, 86, 106689. https://doi.org/10.1016/j.intimp.2020.106689 Cite
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ACOD1 in Immunometabolism and Disease

Mechanistically, several immune receptors, adapter proteins, ubiquitin ligases, and transcription factors formed complex signal transduction networks to control ACOD1 expression in a context-dependent manner.
[Cellular & Molecular Immunology]
Wu, R., Chen, F., Wang, N., Tang, D., & Kang, R. (2020). ACOD1 in immunometabolism and disease. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-0489-5 Cite
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New Tools to Prevent Cancer Growth and Spread: A ‘Clever’ Approach

Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages.
[British Journal of Cancer]
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Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

The authors present an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis.
[International Journal of Molecular Sciences]
Adekoya, T. O., & Richardson, R. M. (2020). Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis. International Journal of Molecular Sciences, 21(12), 4449. https://doi.org/10.3390/ijms21124449 Cite
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Ageing, Metabolism and the Intestine

Scientists review the current state of research of how metabolism and ageing control intestinal stem cell function and epithelial homeostasis.
[EMBO Reports]
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International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis

Investigators present an international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosis with polyangiitis.
[American Journal of Respiratory and Critical Care Medicine]
Moiseev, S., Bossuyt, X., Arimura, Y., Blockmans, D., Csernok, E., Damoiseaux, J., … Cohen Tervaert, J. W. (2020). International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.202005-1628SO Cite
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Inhalational Volatile-Based Sedation for COVID-19 Pneumonia and ARDS

Inhaled volatile anesthetic agents are an abundant resource and readily implementable solution for providing ICU sedation. Inhaled volatile agents may also provide important pulmonary benefits for COVID-19 patients with ARDS that could improve gas exchange and reduce time spent on a ventilator.
[intensive Care Medicine]
Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS | SpringerLink. (n.d.). Retrieved June 26, 2020, from https://link.springer.com/article/10.1007/s00134-020-06154-8 Cite
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MicroRNA and ROS Crosstalk in Cardiac and Pulmonary Diseases

The authors focus on the complex crosstalk between miRNAs and ROS in diseases of the cardiac and pulmonary compartments.
[International Journal of Molecular Sciences]
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Involvement of Glutathione Peroxidases in the Occurrence and Development of Breast Cancers

The authors focus on the molecular mechanism and function of glutathione peroxidases in the occurrence and development of breast cancer.
[Journal of Translational Medicine]
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Targeting the Hippo Pathway in Cancer, Fibrosis, Wound Healing and Regenerative Medicine

Researchers highlight the key findings from studies of Hippo pathway signaling across biological processes and diseases, and discusses new strategies and therapeutic implications of targeting this pathway.
[Nature Reviews Drug Discovery]
Dey, A., Varelas, X., & Guan, K.-L. (2020). Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nature Reviews Drug Discovery, 1–15. https://doi.org/10.1038/s41573-020-0070-z Cite
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