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Lung Cancer Oncogene-Directed Therapy, Fertility and Pregnancy

[Journal Of Thoracic Oncology] The authors performed a narrative review of ex-vivo placenta perfusion studies, pharmacologic characteristics, mutagenicity, animal embryo-fetal development studies, and case reports of pathways to motherhood, pregnancies and egg retrieval while on EGFR, ALK or ROS1-targeted therapy.

Clinical Applications of Stem Cell-Derived Exosomes

[Signal Transduction And Targeted Therapy] Compared to stem cells, stem cell-derived exosomes possess numerous advantages, such as non-immunogenicity, non-infusion toxicity, easy access, effortless preservation, and freedom from tumorigenic potential and ethical issues.

Effect of GVHD on the Gut and Intestinal Microflora

[Transplant Immunology] Gastrointestinal-Graft-versus-host disease causes intestinal immune system disorders, damages intestinal epithelial tissue such as intestinal epithelial cells, goblet, Paneth, and intestinal stem cells, and disrupts the intestinal epithelium's physical and chemical mucosal barriers.

FOXO3: At the Crossroads of Metabolic, Inflammatory, and Tumorigenic Remodeling in the Colon

[American Journal Of Physiology-Gastrointestinal And Liver Physiology] Diminished FOXO3 activity is associated with human diseases such as obesity, metabolic diseases, inflammatory diseases, and cancer.

The MRGPR Family of Receptors in Immunity

[Immunity] The authors focus on the members of this receptor family expressed on immune cells and how they govern immune and neuro-immune pathways underlying various physiological and pathological states.

Can Removal of Zombie Cells Revitalize the Aging Cardiovascular System?

[European Heart Journal] As age advances, senescent cells accumulate in our body organs comprising the cardiovascular system. Notably, these cells stimulate pro-survival pathways and hinder their regenerative capacity.

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