Review

[Seminars In Immunology] Intestinal homeostasis is achieved by the balance among intestinal epithelium, immune cells, and gut microbiota. Gasdermins, a family of membrane pore forming proteins, can trigger rapid inflammatory cell death in the gut, mainly pyroptosis and NETosis.

[IUBMB Life] Researchers review recent findings that indicate Wnt is a regulator of many other cellular physiological activities, such as macropinocytosis, endosome trafficking, protein stability, focal adhesions, and lysosomal activity.

[eBioMedicine] The authors examined the concept of intratumoural heterogeneity and the challenges it poses to achieving long-lasting treatment responses, and focused on the significance of next generation single-cell sequencing in advancing our understanding of melanoma diversity and the unique insights gained from single-cell studies.

[Cell Communication And Signaling] The authors delve into the implications of oncometabolite accumulation in prostate cancer, centering their focus on the consequential epigenetic alterations and impacts on cancer stem cells, with the ultimate goal of outlining novel therapeutic strategies.

[Advanced Healthcare Materials] The authors examine the techniques behind organoid generation, their current and potential applications, and future directions for the field. Brain organoids possess complex architecture containing various neural cell types, synapses, and myelination.

[Clinical and Experimental Immunology] Focusing on the gastrointestinal tract, investigators provide an overview about cellular differentiation in vivo and in organoids and how differentiation in organoids and their derived models is used to advance our understanding of viral, bacterial, and parasitic infection.