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Role of Advanced Glycation End Products in Diabetic Vascular Injury: Molecular Mechanisms and Therapeutic Perspectives

[European Journal Of Medical Research] The authors discuss the formation and accumulation of advanced glycation end products and the subsequent activation of signaling pathways leading to oxidative stress, inflammation, endothelial dysfunction, smooth muscle cell proliferation, extracellular matrix remodeling, and impaired angiogenesis.

Immunoregulatory Nanomedicine for Respiratory Infections

[Nature Reviews Bioengineering] Scientists discuss the design of nanovaccines, including lipid-nanocarrier-based messenger RNA nanovaccines, highlighting engineering strategies for different administration routes, including nasal administration.

The Neurobiology of SARS-CoV-2 Infection

[Nature Reviews Neuroscience] The authors put special emphasis on discussing the methodological difficulties of viral detection in central nervous system (CNS) tissue and discuss immune-based effects contributing to COVID-19-related CNS affection.

B7-H3 Regulates Anti-Tumor Immunity and Promotes Tumor Development in Colorectal Cancer

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors describe the functions played by B7 homologue 3 (B7-H3) in colorectal cancer from both immune and non-immune elements.

Extracellular Vesicles in Venous Thromboembolism and Pulmonary Hypertension

[Journal Of Nanobiotechnology] The roles and importance of extracellular vesicles substantially differs between studies, depending on experimental conditions and parent cell origins of extracellular vesicles that modify the nature of their cargo.

Autocrine/Paracrine Growth Hormone in Cancer Progression

[Endocrine-Related Cancer] In a number of cancers, including carcinoma of the mammary gland, endometrium, liver, prostate, and colon, the expression of growth hormone is independently associated with more advanced clinicopathologic parameters of the cancer.

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