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Converging Bioprinting and Organoids to Better Recapitulate the Tumor Microenvironment

[Trends In Biotechnology] The authors provide a landscape of the latest progress on the convergence of 3D bioprinting and tumor organoids. Furthermore, they discuss the potential to incorporate organ-on-a-chip with bioprinting tumor organoids to improve the biomimicry and predictability of therapeutic performance.

Decoding the Expression Pattern of MUC3A in Gastric Adenocarcinoma: Unveiling the Key to Successful Immunotherapy

[Expert Opinion on Therapeutic Targets] Immunohistochemistry was used to determine the percentage of MUC3A-positive tumor cells in primary and metastatic tumor sites of 190 gastric adenocarcinoma patients.

Targeting Tumor Heterogeneity with Neoantigen-Based Cancer Vaccines

[Cancer Research] Investigators iscuss recent advancements in the design of neoantigen-based cancer vaccines emphasizing the identification, validation, formulation, and targeting of neoantigens while addressing the challenges posed by tumor heterogeneity.

Ubiquitin Signaling in Drosophila Innate Immune Responses

[FEBS Journal] Scientists summarize the molecular signaling pathways regulating immune responses to pathogen infection in Drosophila, with a focus on ubiquitin-dependent control of innate immunity and inflammatory signaling.

A Critical Discussion on the Relationship between E3 Ubiquitin Ligases, Protein Degradation, and Skeletal Muscle Wasting: It’s Not That Simple

[American Journal Of Physiology-Cell Physiology] The authors examine the usefulness of monitoring E3 ubiquitin ligases for determining specific or bulk protein degradation rates in the settings of skeletal muscle atrophy.

Interleukin-1 Family Cytokines in Liver Cell Death: A New Therapeutic Target for Liver Diseases

[Expert Opinion On Therapeutic Targets] The authors summarize recent findings reported in preclinical and clinical studies on mechanisms of liver cell death, alongside participation of IL1 family members consisting of IL1α, ILβ, IL18, and IL33 in liver cell death and their significant implications in liver diseases.

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