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Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy

[Stem Cell Reviews And Reports] Investigators explored novel avenues of research that delve into the distinctive characteristics of CSCs within their surrounding tumor microenvironment.

Activating Transcription Factor 4 in Erythroid Development and β-Thalassemia: A Powerful Regulator with Therapeutic Potential

[Annals of Hematology] Recent research has suggested that activating transcription factor 4 contributes to decreased fetal hemoglobin level through its binding to potent negative regulators of HbF, such as BCL11A and MYB.

Mechanisms of Resistance to Chimeric Antigen Receptor-T Cells in Hematological Malignancies

[Nature Reviews Drug Discovery] The authors summarize the resistance mechanisms to CAR-T cell immunotherapy by analysing CAR-T cell dysfunction, intrinsic tumor resistance, and the immunosuppressive tumor microenvironment.

Snail Transcription Factors as Key Regulators of Chemoresistance, Stemness and Metastasis of Ovarian Cancer Cells

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors summarize published data that reveal Snail proteins not only as key inducers of the EMT in ovarian cancer but also as crucial links between the acquisition of ovarian cancer stem properties and spheroid formation.

Innovative Preconditioning Strategies for Improving the Therapeutic Efficacy of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Gastrointestinal Diseases

[Inflammopharmacology] The authors discuss the application of MSC-EVs in several gastrointestinal (GI) disorders taking into account their mechanism of action, and summarize the challenges and restrictions that need to be overcome to promote their clinical application in the treatment of various GI diseases.

The Innate Immune Factor RPRD2/REAF and Its Role in the Lv2 Restriction of HIV

[mBio] The authors examine lentiviral restriction 2 restriction and the antiviral role of regulation of nuclear pre-mRNA domain containing 2 (RPRD2) and consider potential mechanism(s) of action.

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