Publication

[Arteriosclerosis Thrombosis And Vascular Biology] Researchers combined ex vivo biaxial mechanical testing with multimodality histological examinations to quantify expected age- and sex-dependent structural vulnerability of the ascending aorta in Fbn1C1041G/+ Marfan versus wild-type mice without and with four-week exposures to β-aminopropionitrile, an inhibitor of lysyl oxidase–mediated cross-linking of newly synthesized elastic and collagen fibers.

[Stem Cells And Development] Mouse Trophoblast stem (mTS) cells were cultured on individual ECM components and qPCR analysis revealed that laminin promoted the expression of markers associated with undifferentiated TS cells, fibronectin promoted gene expression associated with syncytiotrophoblast layer II cells and collagen IV promoted differentiation primarily to junctional zone trophoblast.

[Immunity] Using a human tonsil organoid model, scientists tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities.

[Nature Communications] Researchers developed a platform, termed Spatially Patterned Organoid Transfer, consisting of an iron-oxide nanoparticle laden hydrogel and magnetized 3D printer to enable the controlled lifting, transport, and deposition of organoids.

[Nature Communications] Utilizing an approach that combined the use of eye organoids and single-cell RNA sequencing, scientists identified specific glucose transporters and glycolytic genes in retinal progenitors.

[ACS Applied Materials & Interfaces] The authors presented an aerosol-jet- and inkjet-printing-based method to fabricate microelectrode arrays, equipped with high-aspect ratio μ-needle electrodes that penetrate 3D neural network assemblies.