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Cancer Stem Cell News
Insulin-Like Growth Factor (IGF) and Hepatocyte Growth Factor (HGF) in Follicular Fluid Cooperatively Promote the Oncogenesis of High-Grade Serous Carcinoma from Fallopian Tube Epithelial...
[Molecular Carcinogenesis] In a mouse xenograft co-injection model, investigators observed that ovulatory follicular fluid co-injection induced tumorigenesis of serous tubal intraepithelial carcinoma-mimicking cells, FE25.
Neural Cell News
Antigen Recognition Detains CD8+ T Cells at the Blood-Brain Barrier and Contributes to Its Breakdown
[Nature Communications] Investigators showed that brain endothelial cells process and cross-present antigen, leading to effector CD8+ T cell differentiation. Under physiological flow in vitro, endothelial antigen presentation prevented CD8+ T cell crawling and diapedesis resulting in brain endothelial cell apoptosis and blood-brain barrier breakdown.
Neural Cell News
Microcephaly-Associated Protein WDR62 Shuttles From the Golgi Apparatus to the Spindle Poles in Human Neural Progenitors
[eLife] Scientists investigated WDR62 function in corticogenesis through the analysis of a C-terminal truncating mutation. They generated 2D and 3D models of human neurodevelopment, including neuroepithelial stem cells, cerebro-cortical progenitors, terminally differentiated neurons, and cerebral organoids.
Neural Cell News
Activated SIRT1 Contributes to DPT-Induced Glioma Cell Parthanatos by Upregulation of NOX2 and NAT10
[Acta Pharmacologica Sinica] Researchers investigated the role of SIRT1 in deoxypodophyllotoxin (DPT)-induced human glioma cell parthanatos. They showed that DPT activated both polymerase 1 and SIRT1, and induced parthanatos in U87 and U251 glioma cells.
Neural Cell News
Enhancing the Neuroprotective Effect of Squid Outer Skin Astaxanthin Against Rotenone-Induced Neurotoxicity in In-Vitro Model for Parkinson’s Disease
[Food And Chemical Toxicology] Scientists evaluated the effect of astaxanthin in preventing rotenone-induced toxicity of SK-N-SH human neuroblastoma cells in an in vitro model of experimental Parkinsonism.
Neural Cell News
Saikosaponin B2 Ameliorates Depression-Induced Microglia Activation by Inhibiting Ferroptosis-Mediated Neuroinflammation and ER Stress
[Journal Of Ethnopharmacology] Investigators evaluated the anti-inflammatory effect and elucidated underlying molecular mechanisms of saikosaponins B2 in lipopolysaccharide-induced primary microglia and chronic unpredictable mild stress-induced mice model of depression.