Publication

[Analytical Chemistry] Scientists used label-free Raman microscopy to assess human induced pluripotent stem cell differentiation into hepatocyte lineage based on the intracellular chemical content.

[Scientific Reports] In view of the key metabolic role of tribbles related homolog 1 (TRIB1) and the impact of proteasome inhibition on hepatic function, researchers explored TRIB1 regulation in two commonly used human hepatocyte models, transformed cell lines HuH-7 and HepG2.

[Cellular Signalling] The expression of Y-box binding protein 1 in human liver microarray, mice tissues, and primary mouse hepatic stellate cells was validated to be upregulated in several hepatic fibrosis models.

[Nature Communications] Investigators showed a DNA methylation signature for hepatocellular carcinoma detection in liquid biopsies, distinct from normal tissues and blood profiles.

[Advanced Science] Single-nucleus RNA sequencing analysis revealed pathways involved in fatty acid oxidation in DNA methyltransferases ( Dnmt1)-deficient hepatocytes.

[Parasites & Vectors] The functional contributions of miR-29a-3p-Robo1 signaling in liver fibrosis and hepatic stellate cell (HSC) activation were investigated using primary mouse HSCs and the human HSC cell line LX-2.