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YTHDF1-CLOCK Axis Contributes to Pathogenesis of Allergic Airway Inflammation through LLPS

[Cell Reports] Scientists reported that YTHDF1 was highly expressed in allergic airway epithelial cells and asthmatic patients and that it influenced proinflammatory responses.

CPT1A Mediates the Succinylation of SP5 Which Activates Transcription of PDPK1 to Promote the Viability and Glycolysis of Prostate Cancer Cells

[Cancer Biology & Therapy] The authors investigated the role of carnitine palmitoyltransferase 1A (CPT1A), which was a succinyltransferase in the progression of prostate cancer. CCK-8 was used to detect the cell viability.

Comparison Between Stem Cell Therapy and Stem Cell Derived Exosomes on Induced Multiple Sclerosis in Dogs

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Dog models of multiple sclerosis received either a single treatment of stem cells or a single treatment of exosomes intrathecally and the treatment process was evaluated clinically, radiologically, histopathologically, and electron microscopy and cerebrospinal fluid analysis.

Combined Transplantation of hiPSC-NSC and hMSC Ameliorated Neuroinflammation and Promoted Neuroregeneration in Acute Spinal Cord Injury

[Current Stem Cell Research & Therapy] To evaluate the therapeutic effects of combination cells, acute spinal cord injury mice model were established and combined transplantation of hiPSC-neural stem cells and human mesenchymal stem cells into the lesion site immediately after the injury.

Deformable Smart DNA Nanomachine for Synergistic Intracellular Cancer-Related miRNAs Imaging and Chemo-Gene Therapy of Drug-Resistant Tumors

[Small] Deformable smart DNA nanomachines were developed for synergistic intracellular cancer-related miRNAs imaging and chemo-gene therapy of drug-resistant tumors.

An International Learning Collaborative Phase II Trial for Haploidentical Bone Marrow Transplant in Sickle Cell Disease

[Blood] Investigator conducted an international multicenter Phase II clinical trial testing the hypothesis that non-myeloablative related haploidentical BMT with thiotepa and post-transplant cyclophosphamide will result in two-year event-free survival of at least 80%.

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