Tag results:

Publication

Identification of Subtypes in Triple-Negative Breast Cancer Based on Shared Genes Between Immunity and Cancer Stemness

[Journal Of Immunotherapy] Researchers investigated the correlation of immunity and cancer stemness with the molecular subtyping and survival rates in triple negative breast cancer using bioinformatics approaches.

Sustained Antidepressant Effects of Ketamine Metabolite Involve GABAergic Inhibition-Mediated Molecular Dynamics in aPVT Glutamatergic Neurons

[Neuron] Researchers demonstrated that the sustained antidepressant-like behavioral effects of (2S,6S)-hydroxynorketamine in repeatedly stressed animal models involved neurobiological changes in the anterior paraventricular nucleus of the thalamus.

RFX4 Is an Intrinsic Factor for Neuronal Differentiation through Induction of Proneural Genes POU3F2 and NEUROD1

[Cellular and Molecular Life Sciences] The authors utilized a combination of multi-omics data, to identify RFX4 as an upstream regulator of proneural genes. They further validated the role of RFX4 using an in vitro model of neuronal differentiation with RFX4 knock-in and a CRISPR-Cas9 knock-out system.

Establishment and Characterization of Turtle Liver Organoids Provides a Potential Model to Decode Their Unique Adaptations

[Communications Biology] Scientists developed and characterized adult stem cell-derived turtle liver organoids from painted, snapping, and spiny softshell turtles spanning ~175My of evolution, with a subset cryopreserved.

Noncanonical Function of Folate through Folate Receptor 1 during Neural Tube Formation

[Nature Communications] Researchers showed that folate receptor 1 was necessary for the formation of neural tube-like structures in human-cell derived neural organoids.

Bone Morphogenic Protein-4 Availability in the Cardiac Microenvironment Controls Inflammation and Fibrosis in Autoimmune Myocarditis

[Nature Cardiovascular Research] Scientists found that bone morphogenic protein-4 gradients maintained cardiac tissue homeostasis by single-cell transcriptomics analyses of inflamed murine and human myocardial tissues.

Popular