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Neural Cell News
RFX4 Is an Intrinsic Factor for Neuronal Differentiation through Induction of Proneural Genes POU3F2 and NEUROD1
[Cellular and Molecular Life Sciences] The authors utilized a combination of multi-omics data, to identify RFX4 as an upstream regulator of proneural genes. They further validated the role of RFX4 using an in vitro model of neuronal differentiation with RFX4 knock-in and a CRISPR-Cas9 knock-out system.
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Establishment and Characterization of Turtle Liver Organoids Provides a Potential Model to Decode Their Unique Adaptations
[Communications Biology] Scientists developed and characterized adult stem cell-derived turtle liver organoids from painted, snapping, and spiny softshell turtles spanning ~175My of evolution, with a subset cryopreserved.
Newsletters
Noncanonical Function of Folate through Folate Receptor 1 during Neural Tube Formation
[Nature Communications] Researchers showed that folate receptor 1 was necessary for the formation of neural tube-like structures in human-cell derived neural organoids.
Immune Regulation News
Bone Morphogenic Protein-4 Availability in the Cardiac Microenvironment Controls Inflammation and Fibrosis in Autoimmune Myocarditis
[Nature Cardiovascular Research] Scientists found that bone morphogenic protein-4 gradients maintained cardiac tissue homeostasis by single-cell transcriptomics analyses of inflamed murine and human myocardial tissues.
Immune Regulation News
Potentiating the Radiation-Induced Type I Interferon Anti-Tumoral Immune Response by ATM Inhibition in Pancreatic Cancer
[JCI Insight] The authors evaluated the effects of AZD1390 or a structurally related compound AZD0156 on innate immune signaling and found that both inhibitors enhanced radiation-induced Type I interferon expression via the POLIII/RIG-I/MAVS pathway.
Immune Regulation News
UFL1 Ablation in T Cells Suppresses PD-1 UFMylation to Enhance Anti-Tumor Immunity
[Molecular Cell] Researchers reported that mice with conditional knockout (cKO) Ufl1 in T cells exhibit effective tumor control. Single-cell RNA sequencing analysis showed that tumor-infiltrating cytotoxic CD8+ T cells were increased in Ufl1 cKO mice.