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Anti-Cancer Pro-Inflammatory Effects of an IgE Antibody Targeting the Melanoma-Associated Antigen Chondroitin Sulfate Proteoglycan 4 (CSPG4)

[Nature Communications] The authors engineered a monoclonal immunoglobin (Ig) E antibody with human constant domains recognizing CSPG4 to target melanoma. CSPG4 IgE bound to human melanomas including metastases, mediated tumoricidal antibody-dependent cellular cytotoxicity, and stimulated human IgE Fc-receptor-expressing monocytes towards pro-inflammatory phenotypes.

Peptide-Mediated Delivery of CRISPR Enzymes for the Efficient Editing of Primary Human Lymphocytes

[Nature Biomedical Engineering] Scientists showed that the yields of edited primary human lymphocytes could be increased substantially by delivering a CRISPR ribonucleoprotein mixed with an amphiphilic peptide identified through screening.

Memory Profiles Distinguish Cross-Reactive and Virus-Specific T Cell Immunity to Mpox

[Cell Host & Microbe] Researchers assessed cross-reactive and virus-specific CD4+ and CD8+ T cells in healthy individuals and mpox convalescent donors. Cross-reactive T cells were most frequently observed in healthy donors over 45 years.

Obesity Induced Inflammation Exacerbates Clonal Hematopoiesis

[Journal Of Clinical Investigation] Investigators showed that obesity was highly associated with CHIP and that a pro-inflammatory state could potentiate the progression of CHIP to more significant hematologic neoplasia.

Oncogenic Drivers Dictate Immune Control of Acute Myeloid Leukemia

[Nature Communications] Researchers examined immune responses in genetically distinct models of AML and demonstrated that specific AML oncogenes dictate immunogenicity, the quality of immune response, and immune escape through immunoediting.

M2 Macrophages Drive Leukemic Transformation by Imposing Resistance to Phagocytosis and Improving Mitochondrial Metabolism

[Science Advances] Scientists showed that AML-derived macrophages present immunosuppressive and pro-leukemogenic functions, in part related to the acquisition of AML mutations.

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