Publication

[Cell Reports] Scientists found that strong T cell receptor stimulation induces elevated asymmetric cell division rates, and subsequent single-cell-derived colonies comprise both effector and memory precursor cells.

[Cancer Cell] Researchers used a brain endothelial cell-targeted adeno-associated viral (AAV) vector to express LIGHT in the glioma vasculature.

[Science Immunology] Researchers investigated the phenotypic, functional, and transcriptional profiles of CD4+ tissue resident memory T cells (TRM) in the small intestine responding to acute viral infection, revealing a shared gene expression program and chromatin accessibility profile with circulating TH1 and the progressive acquisition of a mature TRM program.

[EMBO Molecular Medicine] In a B-lymphoid cell line, ectopic MYC activity and treatment with IACS-010759 added up to induce oxidative stress, with consequent depletion of reduced glutathione and lethal disruption of redox homeostasis.

[Nature] In a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, the authors synthesized mRNA neoantigen vaccines in real time from surgically resected pancreatic ductal adenocarcinoma tumors.

[Cellular & Molecular Immunology] Researchers performed single-cell RNA-seq analysis of matched CD57+ CD4+ T cells from blood and tonsil samples.