Publication

[Biochemical Pharmacology] The authors reported a liposome loaded with low toxicity and high effectiveness of miriplatin, lipo-miriplatin with high miriplatin loading, and robust stability, exhibiting a superior inhibitory effect on CSCs and non-CSCs.

[Aging] Scientists found that lncRNA-AC026356.1 was upregulated in stem spheres and chemo-resistant lung cancer cells. Fish assay also showed that AC026356.1 was predominantly located in the cytoplasm of lung cancer cells and did not have protein-coding potential.

[Cellular Signalling] Investigators inspected the functions of inorganic pyrophosphatase 1 (PPA1) in colorectal cancer (CRC). The abundance of PPA1 in CRC tissues was analyzed by utilizing publicly available data from the The Cancer Genome Atlas and Human Protein Atlas project.

[Human Cell] The expression of ZNF677 was analyzed by online database and immunohistochemistry, while the methylation level of ZNF677 was determined by the methylation-specific PCR.

[Cancer Investigation] 49 key genes significantly associated with renal cell carcinoma (RCC) stemness were obtained. Next, scientists developed a molecular prognostic signature associated with stemness features of pan-RCC.

[Cancer Cell International] Investigators revealed that the capacity of lymph node metastasis (LNM)-gastric cancer (GC)-small extracellular vesicles educating bone marrow-MSCs was positively correlated with the LNM capacity of GC cells themselves. Fatty acid oxidation metabolic reprogramming was indispensable for this process.