Publication

[Lab On A Chip] The authors presented a thermoplastic-based microphysiological system aiming to model the complex microphysiological structure and function of the endocrine pancreas with concurrent real-time read-out capabilities.

[Nature Biotechnology] Scientists combined high-throughput T cell receptors (TCR) cloning and reactivity validation to train predicTCR, a machine learning classifier that identifies individual tumor-reactive tumor infiltrating lymphocytes (TILs) in an antigen-agnostic manner based on single-TIL RNA sequencing.

[Blood Cancer Journal] The authors assessed the influence of quantified metabolic active tumor volume (MATV) and MATV-dynamics, between pre-apheresis and pre-lymphodepleting chemotherapy MATV, on CAR T-cell outcomes and toxicities in patients with relapsed or refractory large B cell lymphoma.

[ACS Nano] To improve the therapeutic efficiencies of MSCs in osteoarthritis treatment by carbonic anhydrase IX siRNA-based inflammation regulation and Kartogenin-based chondrogenic differentiation, the combination strategy of MSCs and the nanomedicine codelivering KGN and siCA9 was used.

[Molecular Metabolism] Researchers analyzed mouse skeletal muscle at the transition from hindlimb unloading to reloading for changes in transcriptome and extracellular fluid proteome.

[Oncogene] Using genome-wide CRISPR activation and inhibition screens investigators identified multiple drivers and suppressors of prostate cancer metastasis.