Publication

[Nucleic Acids Research] Investigators generated a colon-specific conditional targeted deletion to evaluate epithelial program regulator (EPR) in vivo functions in mice.

[Nature Communications] Scientists demonstrated that DDB1 and CUL4 Associated Factor 1 (DCAF1) phosphorylated enhancer of Zeste Homolog 2 (EZH2) at T367 to augment its nuclear stabilization and enzymatic activity in colon cancer cells.

[Science Advances] Using proteomic analysis, the authors identified bromodomain-containing protein 3 (BRD3), an acetyl-lysine reading epigenetic regulator, as one of nuclear TYRO3’s substrates.

[Cell Death & Disease] Researchers identified cap methyltransferase 1 (CMTR1) as a novel oncogene in colorectal cancer (CRC). Based on The Cancer Genome Atlas database exploration and human tissue microarray analysis, they found that CMTR1 expression was markedly higher in CRC tissues than in adjacent normal tissues.

[Cell & Bioscience] Immunohistochemistry was used to determine claudin 1 (CLDN1) expression in post-chemotherapy liver metastases from 58 colorectal cancer patients. The effects of oxaliplatin on membrane CLDN1 expression were evaluated by flow cytometry, immunofluorescence, and western blotting experiments in vitro and in vivo.

[Cell Communication and Signaling] Scientists reported that serotonin transporter transports serotonin into colorectal cancer cells, enhancing Yes-associated protein (YAP) expression and promoting in vitro and in vivo colon cancer cell growth.