An Endoplasmic Reticulum Stress‐MicroRNA‐26a Feedback Circuit in Nonalcoholic Fatty Liver Disease

Scientists identified a negative feedback loop comprising hepatic endoplasmic reticulum (ER) stress and micro RNA (miRNA)‐26a in nonalcoholic fatty liver disease pathogenesis. Combining miRNA dot blot array and quantitative PCR, they found that miR‐26a was specifically induced by ER stress in liver cells.
[Hepatology]
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The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease

Treatment with either of two bone morphogenetic protein (BMP) inhibitors reduced hepatic triglyceride content in diabetic mice. BMP inhibitor-induced decrease in hepatic triglyceride levels was associated with decreased mRNA encoding Dgat2, an enzyme integral to triglyceride synthesis.
[Scientific Reports]
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Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

Mutation of the hepatocyte nuclear factor (HNF)-1 binding site significantly decreased the promoter activity in hepatocytes, and the promoter carrying the mutated HNF-1 site was not transactivated by co-transfection of HNF-1 in a non-hepatic cell line.
[Scientific Reports]
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PD173074 Blocks G1/S Transition via CUL3-Mediated Ubiquitin Protease in HepG2 and Hep3B Cells

Researchers found fibroblast growth factor receptor 4 (FGFR4) was overexpressed in hepatocellular carcinoma cell lines HepG2 and Hep3B. They used PD173074, an FGFR4 inhibitor, to explore the role of FGFR4 and its underlying mechanism in these cell lines.
[PLoS One]
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Genome-Wide DNA Methylation Analysis of KRAS Mutant Cell Lines

Scientists analyzed the basal CpG methylation of 11 KRAS-mutant and dependent pancreatic cancer cell lines and observed strikingly similar methylation patterns. KRAS knockdown resulted in unique methylation changes with limited overlap between each cell line.
[Scientific Reports]
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A Synergic Approach to Enhance Long-Term Culture and Manipulation of MiaPaCa-2 Pancreatic Cancer Spheroids

In the field of pancreatic cancer, the MiaPaCa-2 cell line is an interesting model for research but it is known for its difficulty to form stable spheroids; also, when formed, spheroids from this cell line are weak and arduous to manage and to harvest for further analyses such as multiple staining and imaging.The authors compared different methods to evaluate which one allowed to better overpass these limitations.
[Scientific Reports]
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The Melatonin Receptor Antagonist Luzindole Induces the Activation of Cellular Stress Responses and Decreases Viability of Rat Pancreatic Stellate Cells

Investigators examined the effects of luzindole, a melatonin receptor‐antagonist, on cultured pancreatic stellate cells.
[Journal of Applied Toxicology]
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Epigenetic Silencing of AATK in Acinar to Ductal Metaplasia in Murine Model of Pancreatic Cancer

By comparing early mouse pancreatic lesions, non-invasive regions showed apoptosis-associated tyrosine kinase (AATK) co-expression in cells with acinar-to-ductal metaplasia, nuclear VAV1 localization, and cell cycle suppression.
[Clinical Epigenetics]
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Overexpression of Gjb4 Impairs Cell Proliferation and Insulin Secretion in Primary Islet Cells

Overexpression of gap junction beta 4 protein in primary islet cells significantly inhibited the proliferation by 47%, reduced insulin secretion of primary islets (46%) and INS-1 cells (51%) and enhanced the rate of apoptosis by 63% in INS-1 cells.
[Molecular Metabolism]
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Identification of a Novel IL-5 Signaling Pathway in Chronic Pancreatitis and Crosstalk with Pancreatic Tumor Cells

The expression of IL-5R and the effects of IL-5 were analyzed in human and murine tumor cells.
[Cell Communication and Signaling]
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GABA Stimulates β-Cell Proliferation through the mTORC1/p70S6K Pathway, an Effect Amplified by Ly49, a Novel GABAA-R Positive Allosteric Modulator

Researchers demonstrated that GABA stimulates β‐cell proliferation via the PI3K/mTORC1/p70S6K pathway in both mouse and human islets.
[Diabetes Obesity & Metabolism]
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