Publication

[Apoptosis] Investigators discovered that circ-STK39 expression increased in pancreatic cancer (PC) tissues and cells, suggesting that circ-STK39 may have a role in PC progression.

[Nature Communications] Scientists showed taht high ploidy large cytoplasmic megakaryocytes are critical negative regulators of HSC and critical for platelet formation.

[Journal Of Experimental Medicine] By using specific genetic tools on both the host and pathogen sides, scientists show that HSC can directly sense B. abortus pathogenic bacteria within the bone marrow via the interaction of the cell surface protein CD150 with the bacterial outer membrane protein Omp25, inducing efficient functional commitment of HSC to the myeloid lineage.

[Advanced Science] Using both zebrafish and mouse models, scientists found that HSCs require SLC39A10 for survival, and provided compelling evidence that SLC39A10 is the master regulator of zinc upregulation in HSCs during early hematopoiesis.

[Cell Reports] Using nonhuman primate models, researchers showed that maternal Western-style diet (mWSD) exposure was associated with persistent pro-inflammatory phenotypes at the transcriptional, metabolic, and functional levels in bone marrow-derived macrophages (BMDMs) from 3-year-old juvenile offspring and in hematopoietic stem and progenitor cells (HSPCs) from fetal and juvenile bone marrow and fetal liver.

[Frontiers In Cell And Developmental Biology] Investigators showed data that supported the notion that the clinically significant effects of the KLF1-E325K mutation were primarily associated with deficiencies in the erythroid lineage but it is possible that deficiencies in the niche might have the potential to exacerbate the condition.