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An All-in-One “4A Hydrogel”: through First-Aid Hemostatic, Antibacterial, Antioxidant, and Angiogenic to Promoting Infected Wound Healing

[Small] Inspired by the strong adhesion of mussels and the enzyme-mimicking activity of nanometallic biomaterials, the authors developed an injectable hydrogel to overcome multiple limitations of current wound dressings.

Epigenetic Dosage Identifies Two Major and Functionally Distinct β Cell Subtypes

[Cell Metabolism] Investigators identified two major subtypes of pancreatic β cells based on histone mark heterogeneity ,βHI and βLO.

Pre-Treatment with IL-6 Potentiates β-Cell Death Induced by Pro-Inflammatory Cytokines

[BMC Molecular and Cell Biology] Pre-treatment with interleukin (IL)-6 sensitized INS-1E cells to cytokine-induced cell death, increasing cytokine-induced inducible nitric oxide synthase and Caspase-3 expression.

Protocol to Generate Human Pluripotent Stem Cell-Derived Pancreatic β Cells through Methionine and Zinc Deprivation

[STAR Protocols] Scientists presented an optimized pancreatic β cell differentiation procedure using human pluripotent stem cells.

Combating Pancreatic Cancer with Ovarian Cancer Cells

[Aging] Researchers showed that ovarian cancer cell SKOV3 could significantly inhibit the proliferation of pancreatic cancer cell SW1990 when they were co-cultured.

Ornithine Aminotransferase Supports Polyamine Synthesis in Pancreatic Cancer

[Nature] Scientists used genetic and pharmacological approaches in human and mouse in vitro and in vivo models to show that PDAC has a distinct dependence on de novo ornithine synthesis from glutamine.

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