A fucose-rich fucoidan was purified from brown seaweed Saccharina japonica, of which the UVB protective effect was investigated in vitro in keratinocytes of HaCaT cells and in vivo in zebrafish. The intracellular ROS levels and the viability of UVB-irradiated HaCaT cells were determined.
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Su, W., Wang, L., Fu, X., Ni, L., Duan, D., Xu, J., & Gao, X. (2020). Protective Effect of a Fucose-Rich Fucoidan Isolated from Saccharina japonica against Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish. Marine Drugs, 18(6), 316. https://doi.org/10.3390/md18060316 Cite
Researchers investigated the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human mesenchymal stem cells (MSCs) during the skin wound healing process. They found that transplantation of umbilical cord blood-MSCs pre-treated with CN enhanced wound closure, granulation, and re-epithelialization at mouse skin wound sites.
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Scientists showed a novel mechanism of melanoma resistance. miR-410-3p was induced by vemurafenib in melanoma cells via ER stress. It drove switching to the invasive phenotype that led to the response and resistance to BRAF inhibition.
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The authors investigated the potential anticancer effect of Abeliophyllum distichum organ extracts against human melanoma SK-MEL-2 cells. The methanol extract of A. distichum leaves exhibited dose- and time-dependent cytotoxicities against SK-MEL-2 cells but not against HDFa human dermal fibroblasts.
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Investigators showed a decrease in reactive oxygen species production and tumor necrosis factor-α expression by methanolic extract (ME) in HaCaT under pro-oxidant and pro-inflammatory conditions, respectively. ME protected HaCaT against oxidative stress and inflammation.
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Mussard, E., Jousselin, S., Cesaro, A., Legrain, B., Lespessailles, E., Esteve, E., Berteina-Raboin, S., & Toumi, H. (2020). Andrographis paniculata and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. Antioxidants, 9(6), 530. https://doi.org/10.3390/antiox9060530 Cite
Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
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Du, J., Xu, Y., Sasada, S., Oo, A. K. K., Hassan, G., Mahmud, H., Khayrani, A. C., Alam, M. J., Kumon, K., Uesaki, R., Afify, S. M., Mansour, H. M., Nair, N., Zahra, M. H., Seno, A., Okada, N., Chen, L., Yan, T., & Seno, M. (2020). Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment. Scientific Reports, 10(1), 9955. https://doi.org/10.1038/s41598-020-66471-2 Cite
Scientists demonstrated that goat putative ESCs were successfully in vitro differentiated into primordial germ cells and oocyte-like cells using bone morphogenetic protein-4 and trans-retinoic acid.
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Researchers performed a mutation significance study of over 1,000 melanoma exomes, combined with a multi-omic analysis of 470 cases from The Cancer Genome Atlas.
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Differentiation assays revealed that developmental pluripotency associated 2 and 4 (Dppa2/4) double knockout mouse ESCs failed to exit pluripotency and differentiate efficiently.
[Nature Structural & Molecular Biology]
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Scientists used multicolor lineage-tracing models to confirm that the mature smooth muscle cell could give rise to a hyperproliferative cell which appeared to promote inflammation via elaboration of complement-dependent anaphylatoxins.
[Proceedings of the National Academy of Sciences of the United States of America]
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Researchers described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]
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