Publication

[Cell Communication And Signaling] Investigators produced an antibody for targeting 1-Pyrroline-5-Carboxylate (P5C) by monoclonal technique and verified that the antibody could oppose the influence of P5C The antibody also inhibited the growth of prostate tumors in an animal model.

[Scientific Reports] The active ingredients and core targets were verified through molecular docking and were validated using PC3 cells in the experimental validation phase.

[Scientific Reports] In vitro experiments with neuroendocrine prostate cancer (NEPC) cell lines demonstrated that CEACAM5-targeted exosomes were specifically taken up by NEPC cells, leading to reduced cellular viability and decreased expression of neuronal markers.

[Nature Communications] Using patient-derived organoids researchers discoveedr that UPP1high tumors exhibited relatively increased sensitivity to Bosutinib and Dasatinib.

[Fractals-Complex Geometry Patterns And Scaling In Nature And Society] Scientists systematically screened the effects of 71 mutations from T cell neoplasms on T cell signalling, cytokine production and in vivo persistence in tumors.

[Genome Research] Scientists exploit its inherent relatedness structure, knowledge of haplotypes from external population reference panels, and the frequent occurrence of monosomies in embryos, whereby the remaining chromosome is phased by default.