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Overall Survival with Palbociclib Plus Letrozole in Advanced Breast Cancer

[Journal Of Clinical Oncology] Researchers reported results for the secondary end point overall survival. Postmenopausal women with ER+/HER2 advanced breast cancer (ABC) without previous systemic therapy for ABC were randomly assigned 2:1 to palbociclib plus letrozole or placebo plus letrozole.

Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration/Invasion and Migrasome Formation to Induce Miscarriage

[ACS Nano] Researchers selected polystyrene nanoplastics (PS-NPs) as a model of plastic particles and treated human trophoblast cells and pregnant mice with PS-NPs at doses near the actual environmental exposure doses of plastic particles in humans.

Deciphering the Molecular Symphony: Unraveling Endothelial-to-Mesenchymal Transition in Corneal Endothelial Cells

[Experimental Eye Research] Scientists established an in vitro model to simulate endothelial-to-mesenchymal transition in corneal endothelial cells.

Hierarchically Assembled Nanofiber Scaffold Guides Long Bone Regeneration by Promoting Osteogenic/Chondrogenic Differentiation of Endogenous Mesenchymal Stem Cells

[Small] A three-dimensional vertically aligned nanofiber scaffold (VAS) was developed with long channels and large pore size. The pore of VAS toward the bone marrow cavity after transplantation enabled the scaffolds to recruit bone marrow MSCs from the bone marrow cavity to the defect area. In vivo, it is found that VAS can significantly shorten gap distance and promote new bone formation compared to the control and collagen groups after 4 and 8 weeks of implantation.

Sequential Gene Expression Analysis of Myelodysplastic Syndrome Transformation Identifies HOXB3 and HOXB7 As the Novel Targets for Mesenchymal Cells in Disease

[BMC Cancer] Researchers described sequential molecular changes and identified biomarkers in MSC of myelodysplastic syndrome (MDS) transformation. MDS-MSC was further isolated and cultured in vitro to determine the potential diagnostic and prognostic value of the identified biomarkers.

The Optimized Priming Effect of FGF-1 and FGF-2 Enhances Preadipocyte Lineage Commitment in Human Adipose-Derived Mesenchymal Stem Cells

[Genes To Cells] To improve safety and graft vitality and to reduce unwanted lineage differentiation, this study refined the methodology by priming adipose-derived MSCs into preadipocytes—unipotent, self-renewing cells.

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