Epigenetic Modulation of Immune Synaptic-Cytoskeletal Networks Potentiates γδ T Cell-Mediated Cytotoxicity in Lung Cancer

Scientists showed that DNA methyltransferase inhibitors upregulated surface molecules on lung cancer cells related to γδ T cell activation using quantitative surface proteomics.
[Nature Communications]
Weng, R. R., Lu, H.-H., Lin, C.-T., Fan, C.-C., Lin, R.-S., Huang, T.-C., Lin, S.-Y., Huang, Y.-J., Juan, Y.-H., Wu, Y.-C., Hung, Z.-C., Liu, C., Lin, X.-H., Hsieh, W.-C., Chiu, T.-Y., Liao, J.-C., Chiu, Y.-L., Chen, S.-Y., Yu, C.-J., & Tsai, H.-C. (2021). Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer. Nature Communications, 12(1), 2163. https://doi.org/10.1038/s41467-021-22433-4 Cite
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Hypoxia-Sensing CAR T Cells Provide Safety and Efficacy in Treating Solid Tumors

Using murine xenograft models, scientists demonstrated that, despite widespread expression of ErbB receptors in healthy organs, the approach provided anti-tumor efficacy without off-tumor toxicity.
[Cell Reports Medicine]
Kosti, P., Opzoomer, J. W., Larios-Martinez, K. I., Henley-Smith, R., Scudamore, C. L., Okesola, M., Taher, M. Y. M., Davies, D. M., Muliaditan, T., Larcombe-Young, D., Woodman, N., Gillett, C. E., Thavaraj, S., Maher, J., & Arnold, J. N. (2021). Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors. Cell Reports Medicine, 0(0). https://doi.org/10.1016/j.xcrm.2021.100227 Cite
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Genetic In Vivo Engineering of Human T Lymphocytes in Mouse Models

Scientists describe how to humanize immunodeficient mice with hematopoietic stem cells and precondition and administer the vector stocks.
[Nature Protocols]
Weidner, T., Agarwal, S., Perian, S., Fusil, F., Braun, G., Hartmann, J., Verhoeyen, E., & Buchholz, C. J. (2021). Genetic in vivo engineering of human T lymphocytes in mouse models. Nature Protocols, 1–31. https://doi.org/10.1038/s41596-021-00510-8 Cite
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Risk Factors and Outcomes of Diffuse Alveolar Haemorrhage after Allogeneic Hematopoietic Stem Cell Transplantation

Investigators explored the occurrence and prognosis of diffuse alveolar haemorrhage after allogeneic hematopoietic stem cell transplantation.
[Bone Marrow Transplantation]
Wu, J., Fu, H.-X., He, Y., Mo, X.-D., Liu, X., Cai, X., Gui, R.-Y., Liu, H.-X., Yan, C.-H., Chen, Y.-H., Chang, Y.-J., Xu, L.-P., Liu, K.-Y., Huang, X.-J., & Zhang, X.-H. (2021). Risk factors and outcomes of diffuse alveolar haemorrhage after allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplantation, 1–11. https://doi.org/10.1038/s41409-021-01293-y Cite
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Frequent Loss-of-Heterozygosity in CRISPR-Cas9–Edited Early Human Embryos

Scientists developed computational pipelines to assess single-cell genomics and transcriptomics datasets from OCT4 CRISPR-Cas9–targeted and control human preimplantation embryos
[Proceedings of the National Academy of Sciences of the United States of America]
Alanis-Lobato, G., Zohren, J., McCarthy, A., Fogarty, N. M. E., Kubikova, N., Hardman, E., Greco, M., Wells, D., Turner, J. M. A., & Niakan, K. K. (2021). Frequent loss-of-heterozygosity in CRISPR-Cas9–edited early human embryos. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2004832117 Cite
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A Novel Full-Human CD22-CAR T Cell Therapy with Potent Activity against CD22low B-ALL

Researchers aimed to develop a new CD22-CAR construct with low immunogenicity and potent activity for treating B acute lymphoblastic leukemia (B-ALL) patients who failed from prior CD22-CAR T cell therapies.
[Blood Cancer Journal]
Tan, Y., Cai, H., Li, C., Deng, B., Song, W., Ling, Z., Hu, G., Yang, Y., Niu, P., Meng, G., Cheng, W., Xu, J., Duan, J., Wang, Z., Yu, X., Feng, X., Zhou, J., & Pan, J. (2021). A novel full-human CD22-CAR T cell therapy with potent activity against CD22 low B-ALL. Blood Cancer Journal, 11(4), 1–6. https://doi.org/10.1038/s41408-021-00465-9 Cite
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Atractylenolide I Enhances Responsiveness to Immune Checkpoint Blockade Therapy by Activating Tumor Antigen Presentation

In syngeneic mouse colorectal cancer (CRC) models and human patient-derived CRC organoid models, atractylenolide I treatment promoted the cytotoxicity of CD8+ T cells and thus profoundly enhanced the efficacy of immune checkpoint blockade therapy.
[Journal of Clinical Investigation]
Xu, H., Jeught, K. V. der, Zhou, Z., Zhang, L., Yu, T., Sun, Y., Li, Y., Wan, C., So, K., Liu, D., Frieden, M., Fang, Y., Mosley, A. L., He, X., Zhang, X., Sandusky, G. E., Liu, Y., Meroueh, S. O., Zhang, C., … Lu, X. (2021). Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI146832 Cite
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Genetic Manipulation and Immortalized Culture of Ex Vivo Primary Human Germinal Center B Cells

Researchers describe a detailed protocol for the purification and ex vivo expansion of primary, nonmalignant human germinal center B cells.
[Nature Protocols]
Caeser, R., Gao, J., Di Re, M., Gong, C., & Hodson, D. J. (2021). Genetic manipulation and immortalized culture of ex vivo primary human germinal center B cells. Nature Protocols, 1–21. https://doi.org/10.1038/s41596-021-00506-4 Cite
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Human Anogenital Monocyte-Derived Dendritic Cells and langerin+cDC2 Are Major HIV Target Cells

Scientsts showed that HIV could penetrate the epithelial surface to interact with sub-epithelial resident mononuclear phagocytes in anogenital explants and defined the full array of subsets that were present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission.
[Nature Communications]
Rhodes, J. W., Botting, R. A., Bertram, K. M., Vine, E. E., Rana, H., Baharlou, H., Vegh, P., O’Neil, T. R., Ashhurst, A. S., Fletcher, J., Parnell, G. P., Graham, J. D., Nasr, N., Lim, J. J. K., Barnouti, L., Haertsch, P., Gosselink, M. P., Di Re, A., Reza, F., … Harman, A. N. (2021). Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells. Nature Communications, 12(1), 2147. https://doi.org/10.1038/s41467-021-22375-x Cite
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Atlas of Breast Cancer Infiltrated B-Lymphocytes Revealed by Paired Single-Cell RNA-Sequencing and Antigen Receptor Profiling

Researchers combined single-cell RNA-sequencing and antigen receptor lineage analysis to characterize a large number of triple-negative breast cancer infiltrated immune cells and report a comprehensive atlas of tumor-infiltrated B-lymphocytes.
[Nature Communications]
Hu, Q., Hong, Y., Qi, P., Lu, G., Mai, X., Xu, S., He, X., Guo, Y., Gao, L., Jing, Z., Wang, J., Cai, T., & Zhang, Y. (2021). Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling. Nature Communications, 12(1), 2186. https://doi.org/10.1038/s41467-021-22300-2 Cite
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Eotaxin-1/CCL11 Is Involved in Cell Migration in Rheumatoid Arthritis

The authors investigated the expression and function of Eotaxin-1 (CCL11) in rheumatoid arthritis fibroblast-like synoviocytes.
[Scientific Reports]
Wakabayashi, K., Isozaki, T., Tsubokura, Y., Fukuse, S., & Kasama, T. (2021). Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis. Scientific Reports, 11(1), 7937. https://doi.org/10.1038/s41598-021-87199-7 Cite
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