High Erythroferrone Expression in CD71+ Erythroid Progenitors Predicts Superior Survival in Myelodysplastic Syndromes

The authors analyzed the expression of erythroferrone and growth/differentiation factor 15 in CD71+ erythroid progenitors of 111 myelodysplastic syndrome patients and assessed their effects on patient survival.
[British Journal of Haematology]
Riabov, V., Mossner, M., Stöhr, A., Jann, J.-C., Streuer, A., Schmitt, N., Knaflic, A., Nowak, V., Weimer, N., Obländer, J., Palme, I., Schumann, C., Baldus, C. D., Schulze, T. J., Wuchter, P., Röhl, H., Jawhar, A., Weiss, C., Boch, T., … Nowak, D. (n.d.). High erythroferrone expression in CD71+ erythroid progenitors predicts superior survival in myelodysplastic syndromes. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.17314 Cite
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MiR-130a Activates the VEGFR2/STAT3/HIF1α Axis to Potentiate the Vasoregenerative Capacity of Endothelial Colony Forming Cells in Hypoxia

The authors identified miR-130a as a mediator of the hypoxic response in human primary endothelial colony forming cells, a well-characterized subtype of endothelial progenitor.
[Molecular Therapy-Nucleic Acids]
Guduric-Fuchs, J., Pedrini, E., Lechner, J., Chambers, S. E., O’Neill, C. L., Melo, J. M. L. de, Pathak, V., Church, R. H., McKeown, S., Bojdo, J., Mcloughlin, K. J., Stitt, A. W., & Medina, R. J. (2021). MiR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony forming cells in hypoxia. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.01.015 Cite
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ATP-Binding Cassette Transporters Restrict Drug Delivery and Efficacy against Brain Tumors Even when Blood-Brain Barrier Integrity Is Lost

A leaky vasculature resulted in higher docetaxel tumor levels compared to normal brain. Nevertheless, Abcb1 could reduce drug distribution and efficacy even in leaky models.
[Cell Reports Medicine]
Gooijer, M. C. de, Kemper, E. M., Buil, L. C. M., Çitirikkaya, C. H., Buckle, T., Beijnen, J. H., & Tellingen, O. van. (2021). ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost. Cell Reports Medicine, 2(1). https://doi.org/10.1016/j.xcrm.2020.100184 Cite
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A GLP-1 Analog Lowers ER Stress and Enhances Protein Folding to Ameliorate Homocysteine-Induced Endothelial Dysfunction

Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase, an important endothelial reticulum chaperone in endothelial cells, and this effect was mediated by AMPK activation.
[Acta Pharmacologica Sinica]
Cheng, C. K., Luo, J.-Y., Lau, C. W., Cho, W. C., Ng, C. F., Ma, R. C. W., Tian, X. Y., & Huang, Y. (2021). A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-020-00589-x Cite
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Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Devices

In order to investigate effects of oxygen microenvironment and matrix composition on the 3D network formation, an upside‐down microfluidic cell culture device capable of generating oxygen gradients was developed.
[Small]
Hsu, H.-H., Ko, P.-L., Wu, H.-M., Lin, H.-C., Wang, C.-K., & Tung, Y.-C. (n.d.). Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Devices. Small, n/a(n/a), 2006091. https://doi.org/https://doi.org/10.1002/smll.202006091 Cite
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Dual Channel Microfluidics for Mimicking the Blood–Brain Barrier

A co-culture of human vascular endothelial cells with pericytes was developed that mimics the blood–brain barrier. This dual channel microfluidics system enabled 3D localization microscopy of the cytoskeleton and 3D single-molecule-sensitive tracing of lipoprotein particles.
[ACS Nano]
Buchroithner, B., Mayr, S., Hauser, F., Priglinger, E., Stangl, H., Santa-Maria, A. R., Deli, M. A., Der, A., Klar, T. A., Axmann, M., Sivun, D., Mairhofer, M., & Jacak, J. (2021). Dual Channel Microfluidics for Mimicking the Blood–Brain Barrier. ACS Nano. https://doi.org/10.1021/acsnano.0c09263 Cite
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The HSP GRP94 Interacts with Macrophage Intracellular Complement C3 and Impacts M2 Profile During ER Stress

Scientists studied GRP94 in M1/LPS + IFNγ and M2/IL-4 primary macrophages derived from human monocytes, in basal and endoplasmic reticulum (ER) stress conditions induced by thapsigargin, an inducer of ER calcium depletion and tunicamycin, an inhibitor of N-glycosylation.
[Cell Death & Disease]
Chaumonnot, K., Masson, S., Sikner, H., Bouchard, A., Baverel, V., Bellaye, P.-S., Collin, B., Garrido, C., & Kohli, E. (2021). The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress. Cell Death & Disease, 12(1), 1–15. https://doi.org/10.1038/s41419-020-03288-x Cite
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T-ALL Can Evolve to Oncogene Independence

Researchers found that the related transcription factor TAL1 was dispensable in several human T-cell acute lymphoblastic leukemia (T-ALL) cell lines that contained SIL-TAL1 chromosomal deletions driving its overexpression, indicating that evolution to oncogene independence could also occur in human T-ALL.
[Leukemia]
Abdulla, H., Vo, A., Shields, B. J., Davies, T. J., Jackson, J. T., Alserihi, R., Viney, E. M., Wong, T., Yan, F., Wong, N. C., Demoen, L., Curtis, D. J., Alexander, W. S., Van Vlierberghe, P., Dickins, R. A., & McCormack, M. P. (2021). T-ALL can evolve to oncogene independence. Leukemia, 1–15. https://doi.org/10.1038/s41375-021-01120-9 Cite
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Phosphodiesterase 4A Confers Resistance to PGE2-Mediated Suppression in CD25+/CD54+ NK Cells

The authors investigated if the modulation of the cytokine environment in lung cancer with IL‐2 or IL‐15 rendered NK cells resistant to suppression by PGE2.
[EMBO Reports]
Chen, Z., Yang, Y., Neo, S. Y., Shi, H., Chen, Y., Wagner, A. K., Larsson, K., Tong, L., Jakobsson, P.-J., Alici, E., Wu, J., Cao, Y., Wang, K., Liu, L. L., Mao, Y., Sarhan, D., & Lundqvist, A. (2021). Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25+/CD54+ NK cells. EMBO Reports, n/a(n/a), e51329. https://doi.org/10.15252/embr.202051329 Cite
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Human Umbilical Cord: Information Mine in Sex-Specific Medicine

The authors review current findings regarding sex differences observed in the umbilical cord, a widely used source of research samples, both in the blood and in the circulating cells, as well as in the different cellular models obtainable from it.
[Life]
Campesi, I., Franconi, F., Montella, A., Dessole, S., & Capobianco, G. (2021). Human Umbilical Cord: Information Mine in Sex-Specific Medicine. Life, 11(1), 52. https://doi.org/10.3390/life11010052 Cite
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In Vivo Cytidine Base Editing of Hepatocytes without Detectable Off-Target Mutations in RNA and DNA

Investigators report unbiased analyses of transcriptome-wide and genome-wide off-target modifications effected by cytidine base editors in the liver of mice with phenylketonuria.
[Nature Biomedical Engineering]
Villiger, L., Rothgangl, T., Witzigmann, D., Oka, R., Lin, P. J. C., Qi, W., Janjuha, S., Berk, C., Ringnalda, F., Beattie, M. B., Stoffel, M., Thöny, B., Hall, J., Rehrauer, H., van Boxtel, R., Tam, Y. K., & Schwank, G. (2021). In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA. Nature Biomedical Engineering, 1–11. https://doi.org/10.1038/s41551-020-00671-z Cite
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