Publication

[Oncogene] Scientists illustrated that tumor-derived interleukin 35 mediated the accelerated resistance of PDAC to gemcitabine (GEM). They observed that GEM resistance can spread from GEM-resistant PDAC cells to GEM-sensitive cells, and that IL-35 was responsible for the propagation of chemoresistance.

[Experimental Eye Research] Scientists investigated the expression of Nephronectin, an ECM protein with pleiotropic functions during organogenesis, disease, and homeostasis, during early embryonic and postnatal development, and in adult mouse corneas.

[Advanced Science] Scientists discovered that trimethylated histone H3 lysine 4 and H3 lysine 27 acetylation modification in the promoter region of YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) enhanced its expression in HCC, and upregulated YTHDF2 in HCC predicted a worse prognosis.

[Heliyon] Scientists evaluated the immunomodulatory effects of Good Manufacturing Practice (GMP)-compliant clinical grade MSCs obtained from four different sources on allogeneic peripheral blood mononuclear cells.

[Scientific Reports] Scientists explored the feasibility of non-invasively monitoring intracavernous injection of adipose tissue-derived stem cells in rat and miniature pig corpus cavernosum using in vivo magnetic resonance imaging.

[Developmental Cell] Using Zfp281 knockout mouse and degron knockin cell models, investigators identified the direct transcriptional activation of Dnmt3a/3b by ZFP281 in PSCs.